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Mechanisms of vesicle formation: Insights from the COP system

1999; Elsevier BV; Volume: 11; Issue: 4 Linguagem: Inglês

10.1016/s0955-0674(99)80063-5

1879-0410

Felix Wieland, Cordula Hartert,

Lipid Membrane Structure and Behavior

The major cytosolic and membrane proteins that represent machinery of coat protein (COP)-coated transport vesicles within the secretory pathway are characterized to date. This has allowed investigation of the molecular mechanisms that underlie the formation of these vesicles. In vitro binding studies and reconstitution experiments have provided insights at the molecular level into the biogenesis of COPII- and COPI-coated vesicles.