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Concentration-Independent Spontaneously Forming Biomimetric Vesicles

2003; American Physical Society; Volume: 91; Issue: 15 Linguagem: Inglês

10.1103/physrevlett.91.158105

1092-0145

Mu‐Ping Nieh, Thad A. Harroun, V. A. Raghunathan, C. J. Glinka, John Katsaras,

Polymer Surface Interaction Studies

In this Letter we present small-angle neutron scattering data from a biomimetic system composed of the phospholipids dimyristoyl and dihexanoyl phosphorylcholine (DMPC and DHPC, respectively). Doping DMPC-DHPC multilamellar vesicles with either the negatively charged lipid dimyristoyl phosphorylglycerol (DMPG, net charge -1) or the divalent cation, calcium (Ca2+), leads to the spontaneous formation of energetically stabilized monodisperse unilamellar vesicles whose radii are concentration independent and in contrast with previous experimental observations.