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Optimization of Slow-Release Tablet Formulations: Containing Montmorillonite I. Properties of Tablets

1980; Taylor & Francis; Volume: 6; Issue: 4 Linguagem: Inglês

10.3109/03639048009068711

1520-5762

James W. McGinity, Michael Harris,

Analytical Methods in Pharmaceuticals

Slow-release tablets containing 20%. sodium sul fathiazole and 30%. magnesium aluminum silicate were prepared by direct compression techniques. Dissolution studies indicated that tablet hardness exerted a negligible influence on drug release from the tablets. During the dissolution process the clay slowly swelled to form a gelatinous hydrated layer around the tablet matrix. At faster stirring speeds, friction between the dissolution basket and the tablet rapidly removed the hydrated boundary region and resulted in a more rapid dissolution rate of the sulfonamide. Faster rates of dissolution were seen in deionized water than in dilute acid since the clay hydrated more readily at the higher pit.