Hydroxychloroquine
1982; American Medical Association; Volume: 100; Issue: 1 Linguagem: Inglês
10.1001/archopht.1982.01030030083006
ISSN1538-3601
Autores Tópico(s)Multiple Myeloma Research and Treatments
Resumo• Ninety-nine patients were treated with hydroxychloroquine sulfate for connective tissue diseases during a seven-year period. All patients received the medication for at least one year and most were treated with a daily dosage of 400 mg. Four patients experienced toxic effects, but no patient sustained permanent loss of visual acuity. Toxicity did not seem to represent a cumulative dosage effect. Funduscopic and visual field examinations at six-month intervals are sufficient to detect the occasional adverse reactions and prevent serious retinal toxic effects when a maximum daily dosage of 400 mg is maintained.
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