High‐affinity interleukin‐2 receptors on blood lymphocytes are decreased during active rheumatoid arthritis
1988; Wiley; Volume: 31; Issue: 9 Linguagem: Inglês
10.1002/art.1780310914
ISSN1529-0131
AutoresPaul Emery, N.C. Wood, Kay C. Gentry, A. Stockman, Ian R. Mackay, Ora Bernard,
Tópico(s)Immune Cell Function and Interaction
ResumoAbstract The expression of receptors for interleukin‐2 (IL‐2R) was examined in patients with active or inactive rheumatoid arthritis (RA) and in control subjects. Unstimulated blood lymphocytes from patients with active RA had increased levels of total IL‐2R, as measured by Tac‐positive cells, compared with the levels found in the other 2 groups. Mitogen‐stimulated cells from patients with active RA expressed less IL‐2R per cell, but the most striking feature was the failure to express high‐affinity IL‐2R. These changes could reflect persistent antigenic stimulation and explain the defective cell‐mediated immunity in RA patients.
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