Effects of Voluntary Running Exercise on Blood Pressure and Renin-Angiotensin System in Spontaneously Hypertensive Rats and Normotensive Wistar-Kyoto Rats.
2000; Center for Academic Publications Japan; Volume: 46; Issue: 4 Linguagem: Inglês
10.3177/jnsv.46.165
ISSN1881-7742
AutoresAtsumi Hayashi, Ai Kobayashi, Rumiko Takahashi, Fumiaki Suzuki, Tora NAKAGAWA, Koichi Kimoto,
Tópico(s)Diet and metabolism studies
ResumoThe effect of a voluntary running exercise on blood pressure and renin-angiotensin system (RAS) was studied in male spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto rats (WKY). SHR and WKY were assigned to either voluntary running exercise or sedentary control groups at 5 wk of age. The systolic blood pressure in the exercised group for both strains of rats was significantly lower than in the sedentary control group. The plasma renin activity (PRA) and plasma renin concentration (PRC) were significantly lower in voluntary running exercised SHR than in sedentary SHR, whereas the same exercise did not result in a lower PRA and PRC in WKY. These results suggested that the blood pressure lowering effect of voluntary running exercise is related to the suppression of RAS in SHR.
Referência(s)