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Diabetes is a proinflammatory state: a translational perspective

2010; Taylor & Francis; Volume: 5; Issue: 1 Linguagem: Inglês

10.1586/eem.09.44

1744-8417

Sridevi Devaraj, Mohan R. Dasu, Ishwarlal Jialal,

Diabetes, Cardiovascular Risks, and Lipoproteins

The diabetic state confers an increased propensity to accelerated atherogenesis. Inflammation is pivotal in atherosclerosis; in addition to the established risk factors, inflammation appears to play a pivotal role in diabetes and its complications. Evidence for increased inflammation includes: increased levels of plasma C-reactive protein, the prototypic marker of inflammation; increased levels of plasminogen-activator inhibitor; increased monocyte superoxide and proinflammatory cytokine release (IL-1, IL-6 and TNF-alpha); increased monocyte adhesion to endothelium; increased NF-kappaB activity; and increased Toll-like receptor 2 and 4 expression and activity in diabetes. Thus, it appears that both Type 1 and Type 2 diabetes are proinflammatory states and that these could contribute to increased diabetic vasculopathies.