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Bioactive Constituents from Three Vismia Species

2003; American Chemical Society; Volume: 66; Issue: 6 Linguagem: Inglês

10.1021/np020566w

1520-6025

Ahmed A. Hussein, Berena Bozzi, Mireya Correa, Todd L. Capson, Thomas A. Kursar, Phyllis D. Coley, Pablo N. Solís, Mahabir P. Gupta,

Bioactive Compounds and Antitumor Agents

Bioassay-guided fractionation of the methanolic extracts of Vismia baccifera, V. jefensis, and V. macrophylla against human breast, CNS, and lung cancer cell lines resulted in the isolation of a new compound, ferruginin C (1), and seven known compounds, ferruginins A (2) and B (3), vismin (4), harunganin (5), vismione B (6), deacetylvismione H (7), and deacetylvismione A (8), as active constituents. In addition, bivismiaquinone (9) and vismiaquinone (10) were obtained as inactive constituents. The structure of ferruginin C was elucidated by spectroscopic means. Compounds 6−8 were the most active, and the cytotoxic activity of compounds 2−5 and 7 is reported for the first time.