Late‐appearing Philadelphia chromosome in a patient with acute nonlymphocytic leukaemia derived from myelodysplastic syndrome: detection of P210‐ and P190‐type bcr/abl fusion gene transcripts at the leukaemic stage
1994; Wiley; Volume: 87; Issue: 1 Linguagem: Inglês
10.1111/j.1365-2141.1994.tb04869.x
ISSN1365-2141
AutoresMakoto Katsuno, Sayuri Yamashita, Shingo Sadamura, Tsukuru Umemura, Jouji Hirata, Junji Nishimura, Hajime Nawata,
Tópico(s)Acute Myeloid Leukemia Research
ResumoSummary. We describe a patient with acute nonlymphocytic leukaemia (ANLL) derived from myelodysplastic syndrome in whom the Philadelphia chromosome (Ph 1 ) first emerged at the late stage of ANLL transformation. Cytogenetically, the Ph 1 chromosome was not detected until the late stage of ANLL transformation, 14 months after the transformation following a 3‐month history of refractory anaemia with excess of blasts. The cells with and without the Ph 1 chromosome had a common abnormal chromosome, t(3;3) (q21;q26). The reverse transcription‐polymerase chain reaction analysis showed no bcr/abl message at diagnosis. However, the mRNA encoding P210 bcr/abl was detected in the early stage of ANLL transformation. Furthermore, the mRNAs encoding both P210 bcr/abl and P190 bcr/abl were detected in the late stage of ANLL transformation when the Ph 1 chromosome was detected by cytogenetic analysis. These evidences support a multistep pathogenesis of leukaemias, and the product of bcr/abl fusion gene may influence the course of disease.
Referência(s)