Separation of enantiomers by lipase-catalyzed fluorous-phase delabeling
2002; Elsevier BV; Volume: 58; Issue: 20 Linguagem: Inglês
10.1016/s0040-4020(02)00258-2
ISSN1464-5416
AutoresSauda Swaleh, Benno Hungerhoff, Helmut Sonnenschein, Fritz Theil,
Tópico(s)Innovative Microfluidic and Catalytic Techniques Innovation
ResumoSimultaneous enantiomer-selective fluorous-phase delabeling and kinetic resolution was achieved by lipase-catalyzed alcoholysis of highly fluorinated esters of racemic alcohols. The separation of the fast-reacting delabeled enantiomers and the slow-reacting fluorous-phase labeled enantiomers was performed very efficiently by partition in an organic/fluorous biphasic solvent system.
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