Proteome of endothelial cell-derived procoagulant microparticles
2005; Wiley; Volume: 5; Issue: 17 Linguagem: Inglês
10.1002/pmic.200402017
ISSN1615-9861
AutoresCristina Banfi, Maura Brioschi, Robin Wait, Shajna Begum, Elisabetta Gianazza, Angela Pirillo, L. Mussoni, Elena Tremoli,
Tópico(s)Phagocytosis and Immune Regulation
ResumoPROTEOMICSVolume 5, Issue 17 p. 4443-4455 Regular Article Proteome of endothelial cell-derived procoagulant microparticles Cristina Banfi Dr., Corresponding Author Cristina Banfi Dr. [email protected] Department of Pharmacological Sciences, University of Milan, Milan, Italy Monzino Cardiologic Center IRCCS, Milan, ItalyMonzino Cardiologic Center and Department of Pharmacological Sciences, Via Balzaretti, 9-20133 Milan, Italy Fax: +39-02-5031-8250/+39-02-647-0594===Search for more papers by this authorMaura Brioschi, Maura Brioschi Department of Pharmacological Sciences, University of Milan, Milan, Italy Monzino Cardiologic Center IRCCS, Milan, ItalySearch for more papers by this authorRobin Wait, Robin Wait Kennedy Institute of Rheumatology Division, Faculty of Medicine, Imperial College London, London, UKSearch for more papers by this authorShajna Begum, Shajna Begum Kennedy Institute of Rheumatology Division, Faculty of Medicine, Imperial College London, London, UKSearch for more papers by this authorElisabetta Gianazza, Elisabetta Gianazza Department of Pharmacological Sciences, University of Milan, Milan, Italy Proteomic and Protein Structure Study Group, University of Milan, ItalySearch for more papers by this authorAngela Pirillo, Angela Pirillo Department of Pharmacological Sciences, University of Milan, Milan, ItalySearch for more papers by this authorLuciana Mussoni, Luciana Mussoni Department of Pharmacological Sciences, University of Milan, Milan, ItalySearch for more papers by this authorElena Tremoli, Elena Tremoli Department of Pharmacological Sciences, University of Milan, Milan, Italy Monzino Cardiologic Center IRCCS, Milan, ItalySearch for more papers by this author Cristina Banfi Dr., Corresponding Author Cristina Banfi Dr. [email protected] Department of Pharmacological Sciences, University of Milan, Milan, Italy Monzino Cardiologic Center IRCCS, Milan, ItalyMonzino Cardiologic Center and Department of Pharmacological Sciences, Via Balzaretti, 9-20133 Milan, Italy Fax: +39-02-5031-8250/+39-02-647-0594===Search for more papers by this authorMaura Brioschi, Maura Brioschi Department of Pharmacological Sciences, University of Milan, Milan, Italy Monzino Cardiologic Center IRCCS, Milan, ItalySearch for more papers by this authorRobin Wait, Robin Wait Kennedy Institute of Rheumatology Division, Faculty of Medicine, Imperial College London, London, UKSearch for more papers by this authorShajna Begum, Shajna Begum Kennedy Institute of Rheumatology Division, Faculty of Medicine, Imperial College London, London, UKSearch for more papers by this authorElisabetta Gianazza, Elisabetta Gianazza Department of Pharmacological Sciences, University of Milan, Milan, Italy Proteomic and Protein Structure Study Group, University of Milan, ItalySearch for more papers by this authorAngela Pirillo, Angela Pirillo Department of Pharmacological Sciences, University of Milan, Milan, ItalySearch for more papers by this authorLuciana Mussoni, Luciana Mussoni Department of Pharmacological Sciences, University of Milan, Milan, ItalySearch for more papers by this authorElena Tremoli, Elena Tremoli Department of Pharmacological Sciences, University of Milan, Milan, Italy Monzino Cardiologic Center IRCCS, Milan, ItalySearch for more papers by this author First published: 17 November 2005 https://doi.org/10.1002/pmic.200402017Citations: 75AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat Abstract Microparticles (MP) are small membrane vesicles that are released from cells upon activation or during apoptosis. Cellular MP in body fluids constitute a heterogeneous population, differing in cellular origin, numbers, size, antigenic composition and functional properties. MP support coagulation by exposure of tissue factor (TF), the initiator of coagulation in vivo. Moreover, MP may transfer bioactive molecules to other cells, thereby stimulating them to produce cytokines, cell-adhesion molecules, growth factors and TF, and modulate endothelial functions. However, a comprehensive characterization of the antigenic composition of MP has been poorly defined. This study describes the protein composition of endothelial cell (EC)-derived MP (EMP) using a proteomic approach. MS analysis indicated the presence of newly described protein such as metabolic enzymes, proteins involved in adhesion and fusion processes, members of protein folding event, cytoskeleton associated proteins and nucleosome. In conclusion, circulating EMP behave as an actual storage pool, able to disseminate blood-borne TF activity and other bioactive effectors, as confirmed by our experiments showing an increased procoagulant activity of EC exposed to EMP. References 1 Bombeli, T., Mueller, M., Haeberli, A., Thromb. Haemost. 1997, 77, 408–423. 2 Rodgers, G. M., FASEB J. 1988, 2, 116–123. 3 Ferro, D., Pittoni, V., Quintarelli, C., Basili, S. et al., Circulation 1997, 95, 1425–1432. 4 Jensen, T., Bjerre-Knudsen, J., Feldt-Rasmussen, B., Deckert, T., Lancet 1989, 1, 461–463. 5 Zeiher, A. M., Drexler, H., Wollschlager, H., Just, H., Circulation 1991, 84, 1984–1992. 6 Van Wijk, M. J., VanBavel, E., Sturk, A., Nieuwland, R., Cardiovasc. 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