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Clinical Trials of Pharmacological Therapies in Acute Heart Failure Syndromes

2010; Lippincott Williams & Wilkins; Volume: 3; Issue: 2 Linguagem: Inglês

10.1161/circheartfailure.109.893222

1941-3297

G. Michael Felker, Peter S. Pang, Kirkwood F. Adams, John G.F. Cleland, Gad Cotter, Kenneth Dickstein, Gerasimos Filippatos, Gregg C. Fonarow, Barry Greenberg, Adrian F. Hernandez, Sadiya S. Khan, Michel Komajda, Marvin A. Konstam, Peter P. Liu, Aldo P. Maggioni, Barry M. Massie, John J.V. McMurray, Mandeep R. Mehra, Marco Metra, John B. OʼConnell, Christopher M. O’Connor, Ileana L. Piña, Piotr Ponikowski, Hani N. Sabbah, John R. Teerlink, James E. Udelson, Clyde W. Yancy, Faı̈ez Zannad, Mihai Gheorghiade,

Cardiac pacing and defibrillation studies

HomeCirculation: Heart FailureVol. 3, No. 2Clinical Trials of Pharmacological Therapies in Acute Heart Failure Syndromes Free AccessResearch ArticlePDF/EPUBAboutView PDFView EPUBSections ToolsAdd to favoritesDownload citationsTrack citationsPermissions ShareShare onFacebookTwitterLinked InMendeleyReddit Jump toFree AccessResearch ArticlePDF/EPUBClinical Trials of Pharmacological Therapies in Acute Heart Failure SyndromesLessons Learned and Directions Forward G. Michael Felker, MD, MHS, Peter S. Pang, MD, Kirkwood F. Adams, MD, John G.F. Cleland, MD, Gad Cotter, MD, Kenneth Dickstein, MD, Gerasimos S. Filippatos, MD, Gregg C. Fonarow, MD, Barry H. Greenberg, MD, Adrian F. Hernandez, MD, MHS, Sadiya Khan, MD, Michel Komajda, MD, Marvin A. Konstam, MD, Peter P. Liu, MD, Aldo P. Maggioni, MD, Barry M. Massie, MD, John J. McMurray, MD, Mandeep Mehra, MD, Marco Metra, MD, John O'Connell, MD, Christopher M. O'Connor, MD, Ileana L. Pina, MD, Piotr Ponikowski, MD, Hani N. Sabbah, PhD, John R. Teerlink, MD, James E. Udelson, MD, Clyde W. Yancy, MD, Faiez Zannad, MD, PhD, Mihai Gheorghiade, MD and G. Michael FelkerG. Michael Felker From the Duke Clinical Research Institute Durham, NC (G.M.F.); Department of Emergency Medicine, Center for Cardiovascular Quality and Outcomes, Northwestern University, Feinberg School of Medicine, Chicago, Ill (P.S.P.); Departments of Medicine and Radiology, School of Medicine, University of North Carolina at Chapel Hill, NC (K.F.A.); Department of Cardiology, Castle Hill Hospital, University of Hull, Kingston-upon-Hull, UK (J.G.F.C.); Momentum Research Inc, Durham, NC (G.C.); Stavanger University Hospital, Stavanger, Norway; Institute of Internal Medicine, University of Bergen, Bergen, Norway (K.D.); Athens University Hospital Attikon, Athens, Greece (G.S.F.); Ahmanson-UCLA Cardiomyopathy Center, David Geffen UCLA Medical Center, Los Angeles, Calif (G.C.F.); University of California, San Diego, San Diego, Calif (B.G.); Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Ill (S.K.); Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC (A.F.H.); University Pierre et Marie Curie Paris, Assistance Publique Hopitaux de Paris, Paris, France (M.K.); Cardiovascular Center, Tufts Medical Center, and Tufts University School of Medicine, Boston, Mass (M.A.K.); Institute of Circulatory and Respiratory Health, Canadian Institutes of Health, Toronto General Hospital, University of Toronto (P.P.L.); ANMCO Research Center, Firenze, Italy (A.P.M.); University of California, San Francisco, Calif, Cardiology Division, San Francisco Veterans Affairs Medical Center, San Francisco, Calif (B.M.M.); BHF Cardiovascular Research Centre, University of Glasgow, Glasgow, Scotland (J.J.M.); University of Maryland School of Medicine, Baltimore, Md (M.M.); Department of Experimental and Applied Medicine, University and Civil Hospital of Brescia, Brescia, Italy (M.M.); Division of Cardiology, Feinberg School of Medicine, Chicago, Ill (J.O.C.); Duke Heart Center, Division of Clinical Pharmacology, Duke University Medical Center, Durham, NC (C.M.O.); Case Western Reserve University, Cleveland, Ohio (I.L.P.); Medical University, Faculty of Health Sciences, Clinical Military Hospital, Poland (P.P.); Department of Medicine, Henry Ford Hospital, Detroit, Mich (H.N.S.); University of California, San Francisco, and Veterans Affairs Medical Center, San Francisco, Calif (J.R.T.); Division of Cardiology, Tufts Medical Center, Boston, Mass (J.E.U.); Baylor Heart and Vascular Institute, Dallas, Tex (C.W.Y.); CHU Cardiology Department, Nancy University, Nancy, France (F.Z.); and Department of Medicine, Center Cardiovascular Quality and Outcomes, Northwestern University, Feinberg School of Medicine, Chicago, Ill (M.G.). , Peter S. PangPeter S. Pang From the Duke Clinical Research Institute Durham, NC (G.M.F.); Department of Emergency Medicine, Center for Cardiovascular Quality and Outcomes, Northwestern University, Feinberg School of Medicine, Chicago, Ill (P.S.P.); Departments of Medicine and Radiology, School of Medicine, University of North Carolina at Chapel Hill, NC (K.F.A.); Department of Cardiology, Castle Hill Hospital, University of Hull, Kingston-upon-Hull, UK (J.G.F.C.); Momentum Research Inc, Durham, NC (G.C.); Stavanger University Hospital, Stavanger, Norway; Institute of Internal Medicine, University of Bergen, Bergen, Norway (K.D.); Athens University Hospital Attikon, Athens, Greece (G.S.F.); Ahmanson-UCLA Cardiomyopathy Center, David Geffen UCLA Medical Center, Los Angeles, Calif (G.C.F.); University of California, San Diego, San Diego, Calif (B.G.); Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Ill (S.K.); Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC (A.F.H.); University Pierre et Marie Curie Paris, Assistance Publique Hopitaux de Paris, Paris, France (M.K.); Cardiovascular Center, Tufts Medical Center, and Tufts University School of Medicine, Boston, Mass (M.A.K.); Institute of Circulatory and Respiratory Health, Canadian Institutes of Health, Toronto General Hospital, University of Toronto (P.P.L.); ANMCO Research Center, Firenze, Italy (A.P.M.); University of California, San Francisco, Calif, Cardiology Division, San Francisco Veterans Affairs Medical Center, San Francisco, Calif (B.M.M.); BHF Cardiovascular Research Centre, University of Glasgow, Glasgow, Scotland (J.J.M.); University of Maryland School of Medicine, Baltimore, Md (M.M.); Department of Experimental and Applied Medicine, University and Civil Hospital of Brescia, Brescia, Italy (M.M.); Division of Cardiology, Feinberg School of Medicine, Chicago, Ill (J.O.C.); Duke Heart Center, Division of Clinical Pharmacology, Duke University Medical Center, Durham, NC (C.M.O.); Case Western Reserve University, Cleveland, Ohio (I.L.P.); Medical University, Faculty of Health Sciences, Clinical Military Hospital, Poland (P.P.); Department of Medicine, Henry Ford Hospital, Detroit, Mich (H.N.S.); University of California, San Francisco, and Veterans Affairs Medical Center, San Francisco, Calif (J.R.T.); Division of Cardiology, Tufts Medical Center, Boston, Mass (J.E.U.); Baylor Heart and Vascular Institute, Dallas, Tex (C.W.Y.); CHU Cardiology Department, Nancy University, Nancy, France (F.Z.); and Department of Medicine, Center Cardiovascular Quality and Outcomes, Northwestern University, Feinberg School of Medicine, Chicago, Ill (M.G.). , Kirkwood F. AdamsKirkwood F. Adams From the Duke Clinical Research Institute Durham, NC (G.M.F.); Department of Emergency Medicine, Center for Cardiovascular Quality and Outcomes, Northwestern University, Feinberg School of Medicine, Chicago, Ill (P.S.P.); Departments of Medicine and Radiology, School of Medicine, University of North Carolina at Chapel Hill, NC (K.F.A.); Department of Cardiology, Castle Hill Hospital, University of Hull, Kingston-upon-Hull, UK (J.G.F.C.); Momentum Research Inc, Durham, NC (G.C.); Stavanger University Hospital, Stavanger, Norway; Institute of Internal Medicine, University of Bergen, Bergen, Norway (K.D.); Athens University Hospital Attikon, Athens, Greece (G.S.F.); Ahmanson-UCLA Cardiomyopathy Center, David Geffen UCLA Medical Center, Los Angeles, Calif (G.C.F.); University of California, San Diego, San Diego, Calif (B.G.); Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Ill (S.K.); Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC (A.F.H.); University Pierre et Marie Curie Paris, Assistance Publique Hopitaux de Paris, Paris, France (M.K.); Cardiovascular Center, Tufts Medical Center, and Tufts University School of Medicine, Boston, Mass (M.A.K.); Institute of Circulatory and Respiratory Health, Canadian Institutes of Health, Toronto General Hospital, University of Toronto (P.P.L.); ANMCO Research Center, Firenze, Italy (A.P.M.); University of California, San Francisco, Calif, Cardiology Division, San Francisco Veterans Affairs Medical Center, San Francisco, Calif (B.M.M.); BHF Cardiovascular Research Centre, University of Glasgow, Glasgow, Scotland (J.J.M.); University of Maryland School of Medicine, Baltimore, Md (M.M.); Department of Experimental and Applied Medicine, University and Civil Hospital of Brescia, Brescia, Italy (M.M.); Division of Cardiology, Feinberg School of Medicine, Chicago, Ill (J.O.C.); Duke Heart Center, Division of Clinical Pharmacology, Duke University Medical Center, Durham, NC (C.M.O.); Case Western Reserve University, Cleveland, Ohio (I.L.P.); Medical University, Faculty of Health Sciences, Clinical Military Hospital, Poland (P.P.); Department of Medicine, Henry Ford Hospital, Detroit, Mich (H.N.S.); University of California, San Francisco, and Veterans Affairs Medical Center, San Francisco, Calif (J.R.T.); Division of Cardiology, Tufts Medical Center, Boston, Mass (J.E.U.); Baylor Heart and Vascular Institute, Dallas, Tex (C.W.Y.); CHU Cardiology Department, Nancy University, Nancy, France (F.Z.); and Department of Medicine, Center Cardiovascular Quality and Outcomes, Northwestern University, Feinberg School of Medicine, Chicago, Ill (M.G.). , John G.F. ClelandJohn G.F. Cleland From the Duke Clinical Research Institute Durham, NC (G.M.F.); Department of Emergency Medicine, Center for Cardiovascular Quality and Outcomes, Northwestern University, Feinberg School of Medicine, Chicago, Ill (P.S.P.); Departments of Medicine and Radiology, School of Medicine, University of North Carolina at Chapel Hill, NC (K.F.A.); Department of Cardiology, Castle Hill Hospital, University of Hull, Kingston-upon-Hull, UK (J.G.F.C.); Momentum Research Inc, Durham, NC (G.C.); Stavanger University Hospital, Stavanger, Norway; Institute of Internal Medicine, University of Bergen, Bergen, Norway (K.D.); Athens University Hospital Attikon, Athens, Greece (G.S.F.); Ahmanson-UCLA Cardiomyopathy Center, David Geffen UCLA Medical Center, Los Angeles, Calif (G.C.F.); University of California, San Diego, San Diego, Calif (B.G.); Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Ill (S.K.); Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC (A.F.H.); University Pierre et Marie Curie Paris, Assistance Publique Hopitaux de Paris, Paris, France (M.K.); Cardiovascular Center, Tufts Medical Center, and Tufts University School of Medicine, Boston, Mass (M.A.K.); Institute of Circulatory and Respiratory Health, Canadian Institutes of Health, Toronto General Hospital, University of Toronto (P.P.L.); ANMCO Research Center, Firenze, Italy (A.P.M.); University of California, San Francisco, Calif, Cardiology Division, San Francisco Veterans Affairs Medical Center, San Francisco, Calif (B.M.M.); BHF Cardiovascular Research Centre, University of Glasgow, Glasgow, Scotland (J.J.M.); University of Maryland School of Medicine, Baltimore, Md (M.M.); Department of Experimental and Applied Medicine, University and Civil Hospital of Brescia, Brescia, Italy (M.M.); Division of Cardiology, Feinberg School of Medicine, Chicago, Ill (J.O.C.); Duke Heart Center, Division of Clinical Pharmacology, Duke University Medical Center, Durham, NC (C.M.O.); Case Western Reserve University, Cleveland, Ohio (I.L.P.); Medical University, Faculty of Health Sciences, Clinical Military Hospital, Poland (P.P.); Department of Medicine, Henry Ford Hospital, Detroit, Mich (H.N.S.); University of California, San Francisco, and Veterans Affairs Medical Center, San Francisco, Calif (J.R.T.); Division of Cardiology, Tufts Medical Center, Boston, Mass (J.E.U.); Baylor Heart and Vascular Institute, Dallas, Tex (C.W.Y.); CHU Cardiology Department, Nancy University, Nancy, France (F.Z.); and Department of Medicine, Center Cardiovascular Quality and Outcomes, Northwestern University, Feinberg School of Medicine, Chicago, Ill (M.G.). , Gad CotterGad Cotter From the Duke Clinical Research Institute Durham, NC (G.M.F.); Department of Emergency Medicine, Center for Cardiovascular Quality and Outcomes, Northwestern University, Feinberg School of Medicine, Chicago, Ill (P.S.P.); Departments of Medicine and Radiology, School of Medicine, University of North Carolina at Chapel Hill, NC (K.F.A.); Department of Cardiology, Castle Hill Hospital, University of Hull, Kingston-upon-Hull, UK (J.G.F.C.); Momentum Research Inc, Durham, NC (G.C.); Stavanger University Hospital, Stavanger, Norway; Institute of Internal Medicine, University of Bergen, Bergen, Norway (K.D.); Athens University Hospital Attikon, Athens, Greece (G.S.F.); Ahmanson-UCLA Cardiomyopathy Center, David Geffen UCLA Medical Center, Los Angeles, Calif (G.C.F.); University of California, San Diego, San Diego, Calif (B.G.); Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Ill (S.K.); Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC (A.F.H.); University Pierre et Marie Curie Paris, Assistance Publique Hopitaux de Paris, Paris, France (M.K.); Cardiovascular Center, Tufts Medical Center, and Tufts University School of Medicine, Boston, Mass (M.A.K.); Institute of Circulatory and Respiratory Health, Canadian Institutes of Health, Toronto General Hospital, University of Toronto (P.P.L.); ANMCO Research Center, Firenze, Italy (A.P.M.); University of California, San Francisco, Calif, Cardiology Division, San Francisco Veterans Affairs Medical Center, San Francisco, Calif (B.M.M.); BHF Cardiovascular Research Centre, University of Glasgow, Glasgow, Scotland (J.J.M.); University of Maryland School of Medicine, Baltimore, Md (M.M.); Department of Experimental and Applied Medicine, University and Civil Hospital of Brescia, Brescia, Italy (M.M.); Division of Cardiology, Feinberg School of Medicine, Chicago, Ill (J.O.C.); Duke Heart Center, Division of Clinical Pharmacology, Duke University Medical Center, Durham, NC (C.M.O.); Case Western Reserve University, Cleveland, Ohio (I.L.P.); Medical University, Faculty of Health Sciences, Clinical Military Hospital, Poland (P.P.); Department of Medicine, Henry Ford Hospital, Detroit, Mich (H.N.S.); University of California, San Francisco, and Veterans Affairs Medical Center, San Francisco, Calif (J.R.T.); Division of Cardiology, Tufts Medical Center, Boston, Mass (J.E.U.); Baylor Heart and Vascular Institute, Dallas, Tex (C.W.Y.); CHU Cardiology Department, Nancy University, Nancy, France (F.Z.); and Department of Medicine, Center Cardiovascular Quality and Outcomes, Northwestern University, Feinberg School of Medicine, Chicago, Ill (M.G.). , Kenneth DicksteinKenneth Dickstein From the Duke Clinical Research Institute Durham, NC (G.M.F.); Department of Emergency Medicine, Center for Cardiovascular Quality and Outcomes, Northwestern University, Feinberg School of Medicine, Chicago, Ill (P.S.P.); Departments of Medicine and Radiology, School of Medicine, University of North Carolina at Chapel Hill, NC (K.F.A.); Department of Cardiology, Castle Hill Hospital, University of Hull, Kingston-upon-Hull, UK (J.G.F.C.); Momentum Research Inc, Durham, NC (G.C.); Stavanger University Hospital, Stavanger, Norway; Institute of Internal Medicine, University of Bergen, Bergen, Norway (K.D.); Athens University Hospital Attikon, Athens, Greece (G.S.F.); Ahmanson-UCLA Cardiomyopathy Center, David Geffen UCLA Medical Center, Los Angeles, Calif (G.C.F.); University of California, San Diego, San Diego, Calif (B.G.); Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Ill (S.K.); Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC (A.F.H.); University Pierre et Marie Curie Paris, Assistance Publique Hopitaux de Paris, Paris, France (M.K.); Cardiovascular Center, Tufts Medical Center, and Tufts University School of Medicine, Boston, Mass (M.A.K.); Institute of Circulatory and Respiratory Health, Canadian Institutes of Health, Toronto General Hospital, University of Toronto (P.P.L.); ANMCO Research Center, Firenze, Italy (A.P.M.); University of California, San Francisco, Calif, Cardiology Division, San Francisco Veterans Affairs Medical Center, San Francisco, Calif (B.M.M.); BHF Cardiovascular Research Centre, University of Glasgow, Glasgow, Scotland (J.J.M.); University of Maryland School of Medicine, Baltimore, Md (M.M.); Department of Experimental and Applied Medicine, University and Civil Hospital of Brescia, Brescia, Italy (M.M.); Division of Cardiology, Feinberg School of Medicine, Chicago, Ill (J.O.C.); Duke Heart Center, Division of Clinical Pharmacology, Duke University Medical Center, Durham, NC (C.M.O.); Case Western Reserve University, Cleveland, Ohio (I.L.P.); Medical University, Faculty of Health Sciences, Clinical Military Hospital, Poland (P.P.); Department of Medicine, Henry Ford Hospital, Detroit, Mich (H.N.S.); University of California, San Francisco, and Veterans Affairs Medical Center, San Francisco, Calif (J.R.T.); Division of Cardiology, Tufts Medical Center, Boston, Mass (J.E.U.); Baylor Heart and Vascular Institute, Dallas, Tex (C.W.Y.); CHU Cardiology Department, Nancy University, Nancy, France (F.Z.); and Department of Medicine, Center Cardiovascular Quality and Outcomes, Northwestern University, Feinberg School of Medicine, Chicago, Ill (M.G.). , Gerasimos S. FilippatosGerasimos S. Filippatos From the Duke Clinical Research Institute Durham, NC (G.M.F.); Department of Emergency Medicine, Center for Cardiovascular Quality and Outcomes, Northwestern University, Feinberg School of Medicine, Chicago, Ill (P.S.P.); Departments of Medicine and Radiology, School of Medicine, University of North Carolina at Chapel Hill, NC (K.F.A.); Department of Cardiology, Castle Hill Hospital, University of Hull, Kingston-upon-Hull, UK (J.G.F.C.); Momentum Research Inc, Durham, NC (G.C.); Stavanger University Hospital, Stavanger, Norway; Institute of Internal Medicine, University of Bergen, Bergen, Norway (K.D.); Athens University Hospital Attikon, Athens, Greece (G.S.F.); Ahmanson-UCLA Cardiomyopathy Center, David Geffen UCLA Medical Center, Los Angeles, Calif (G.C.F.); University of California, San Diego, San Diego, Calif (B.G.); Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Ill (S.K.); Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC (A.F.H.); University Pierre et Marie Curie Paris, Assistance Publique Hopitaux de Paris, Paris, France (M.K.); Cardiovascular Center, Tufts Medical Center, and Tufts University School of Medicine, Boston, Mass (M.A.K.); Institute of Circulatory and Respiratory Health, Canadian Institutes of Health, Toronto General Hospital, University of Toronto (P.P.L.); ANMCO Research Center, Firenze, Italy (A.P.M.); University of California, San Francisco, Calif, Cardiology Division, San Francisco Veterans Affairs Medical Center, San Francisco, Calif (B.M.M.); BHF Cardiovascular Research Centre, University of Glasgow, Glasgow, Scotland (J.J.M.); University of Maryland School of Medicine, Baltimore, Md (M.M.); Department of Experimental and Applied Medicine, University and Civil Hospital of Brescia, Brescia, Italy (M.M.); Division of Cardiology, Feinberg School of Medicine, Chicago, Ill (J.O.C.); Duke Heart Center, Division of Clinical Pharmacology, Duke University Medical Center, Durham, NC (C.M.O.); Case Western Reserve University, Cleveland, Ohio (I.L.P.); Medical University, Faculty of Health Sciences, Clinical Military Hospital, Poland (P.P.); Department of Medicine, Henry Ford Hospital, Detroit, Mich (H.N.S.); University of California, San Francisco, and Veterans Affairs Medical Center, San Francisco, Calif (J.R.T.); Division of Cardiology, Tufts Medical Center, Boston, Mass (J.E.U.); Baylor Heart and Vascular Institute, Dallas, Tex (C.W.Y.); CHU Cardiology Department, Nancy University, Nancy, France (F.Z.); and Department of Medicine, Center Cardiovascular Quality and Outcomes, Northwestern University, Feinberg School of Medicine, Chicago, Ill (M.G.). , Gregg C. FonarowGregg C. Fonarow From the Duke Clinical Research Institute Durham, NC (G.M.F.); Department of Emergency Medicine, Center for Cardiovascular Quality and Outcomes, Northwestern University, Feinberg School of Medicine, Chicago, Ill (P.S.P.); Departments of Medicine and Radiology, School of Medicine, University of North Carolina at Chapel Hill, NC (K.F.A.); Department of Cardiology, Castle Hill Hospital, University of Hull, Kingston-upon-Hull, UK (J.G.F.C.); Momentum Research Inc, Durham, NC (G.C.); Stavanger University Hospital, Stavanger, Norway; Institute of Internal Medicine, University of Bergen, Bergen, Norway (K.D.); Athens University Hospital Attikon, Athens, Greece (G.S.F.); Ahmanson-UCLA Cardiomyopathy Center, David Geffen UCLA Medical Center, Los Angeles, Calif (G.C.F.); University of California, San Diego, San Diego, Calif (B.G.); Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Ill (S.K.); Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC (A.F.H.); University Pierre et Marie Curie Paris, Assistance Publique Hopitaux de Paris, Paris, France (M.K.); Cardiovascular Center, Tufts Medical Center, and Tufts University School of Medicine, Boston, Mass (M.A.K.); Institute of Circulatory and Respiratory Health, Canadian Institutes of Health, Toronto General Hospital, University of Toronto (P.P.L.); ANMCO Research Center, Firenze, Italy (A.P.M.); University of California, San Francisco, Calif, Cardiology Division, San Francisco Veterans Affairs Medical Center, San Francisco, Calif (B.M.M.); BHF Cardiovascular Research Centre, University of Glasgow, Glasgow, Scotland (J.J.M.); University of Maryland School of Medicine, Baltimore, Md (M.M.); Department of Experimental and Applied Medicine, University and Civil Hospital of Brescia, Brescia, Italy (M.M.); Division of Cardiology, Feinberg School of Medicine, Chicago, Ill (J.O.C.); Duke Heart Center, Division of Clinical Pharmacology, Duke University Medical Center, Durham, NC (C.M.O.); Case Western Reserve University, Cleveland, Ohio (I.L.P.); Medical University, Faculty of Health Sciences, Clinical Military Hospital, Poland (P.P.); Department of Medicine, Henry Ford Hospital, Detroit, Mich (H.N.S.); University of California, San Francisco, and Veterans Affairs Medical Center, San Francisco, Calif (J.R.T.); Division of Cardiology, Tufts Medical Center, Boston, Mass (J.E.U.); Baylor Heart and Vascular Institute, Dallas, Tex (C.W.Y.); CHU Cardiology Department, Nancy University, Nancy, France (F.Z.); and Department of Medicine, Center Cardiovascular Quality and Outcomes, Northwestern University, Feinberg School of Medicine, Chicago, Ill (M.G.). , Barry H. GreenbergBarry H. Greenberg From the Duke Clinical Research Institute Durham, NC (G.M.F.); Department of Emergency Medicine, Center for Cardiovascular Quality and Outcomes, Northwestern University, Feinberg School of Medicine, Chicago, Ill (P.S.P.); Departments of Medicine and Radiology, School of Medicine, University of North Carolina at Chapel Hill, NC (K.F.A.); Department of Cardiology, Castle Hill Hospital, University of Hull, Kingston-upon-Hull, UK (J.G.F.C.); Momentum Research Inc, Durham, NC (G.C.); Stavanger University Hospital, Stavanger, Norway; Institute of Internal Medicine, University of Bergen, Bergen, Norway (K.D.); Athens University Hospital Attikon, Athens, Greece (G.S.F.); Ahmanson-UCLA Cardiomyopathy Center, David Geffen UCLA Medical Center, Los Angeles, Calif (G.C.F.); University of California, San Diego, San Diego, Calif (B.G.); Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Ill (S.K.); Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC (A.F.H.); University Pierre et Marie Curie Paris, Assistance Publique Hopitaux de Paris, Paris, France (M.K.); Cardiovascular Center, Tufts Medical Center, and Tufts University School of Medicine, Boston, Mass (M.A.K.); Institute of Circulatory and Respiratory Health, Canadian Institutes of Health, Toronto General Hospital, University of Toronto (P.P.L.); ANMCO Research Center, Firenze, Italy (A.P.M.); University of California, San Francisco, Calif, Cardiology Division, San Francisco Veterans Affairs Medical Center, San Francisco, Calif (B.M.M.); BHF Cardiovascular Research Centre, University of Glasgow, Glasgow, Scotland (J.J.M.); University of Maryland School of Medicine, Baltimore, Md (M.M.); Department of Experimental and Applied Medicine, University and Civil Hospital of Brescia, Brescia, Italy (M.M.); Division of Cardiology, Feinberg School of Medicine, Chicago, Ill (J.O.C.); Duke Heart Center, Division of Clinical Pharmacology, Duke University Medical Center, Durham, NC (C.M.O.); Case Western Reserve University, Cleveland, Ohio (I.L.P.); Medical University, Faculty of Health Sciences, Clinical Military Hospital, Poland (P.P.); Department of Medicine, Henry Ford Hospital, Detroit, Mich (H.N.S.); University of California, San Francisco, and Veterans Affairs Medical Center, San Francisco, Calif (J.R.T.); Division of Cardiology, Tufts Medical Center, Boston, Mass (J.E.U.); Baylor Heart and Vascular Institute, Dallas, Tex (C.W.Y.); CHU Cardiology Department, Nancy University, Nancy, France (F.Z.); and Department of Medicine, Center Cardiovascular Quality and Outcomes, Northwestern University, Feinberg School of Medicine, Chicago, Ill (M.G.). , Adrian F. HernandezAdrian F. Hernandez From the Duke Clinical Research Institute Durham, NC (G.M.F.); Department of Emergency Medicine, Center for Cardiovascular Quality and Outcomes, Northwestern University, Feinberg School of Medicine, Chicago, Ill (P.S.P.); Departments of Medicine and Radiology, School of Medicine, University of North Carolina at Chapel Hill, NC (K.F.A.); Department of Cardiology, Castle Hill Hospital, University of Hull, Kingston-upon-Hull, UK (J.G.F.C.); Momentum Research Inc, Durham, NC (G.C.); Stavanger University Hospital, Stavanger, Norway; Institute of Internal Medicine, University of Bergen, Bergen, Norway (K.D.); Athens University Hospital Attikon, Athens, Greece (G.S.F.); Ahmanson-UCLA Cardiomyopathy Center, David Geffen UCLA Medical Center, Los Angeles, Calif (G.C.F.); University of California, San Diego, San Diego, Calif (B.G.); Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Ill (S.K.); Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC (A.F.H.); University Pierre et Marie Curie Paris, Assistance Publique Hopitaux de Paris, Paris, France (M.K.); Cardiovascular Center, Tufts Medical Center, and Tufts University School of Medicine, Boston, Mass (M.A.K.); Institute of Circulatory and Respiratory Health, Canadian Institutes of Health, Toronto General Hospital, University of Toronto (P.P.L.); ANMCO Research Center, Firenze, Italy (A.P.M.); University of California, San Francisco, Calif, Cardiology Division, San Francisco Veterans Affairs Medical Center, San Francisco, Calif (B.M.M.); BHF Cardiovascular Research Centre, University of Glasgow, Glasgow, Scotland (J.J.M.); University of Maryland School of Medicine, Baltimore, Md (M.M.); Department of Experimental and Applied Medicine, University and Civil Hospital of Brescia, Brescia, Italy (M.M.); Division of Cardiology, Feinberg School of Medicine, Chicago, Ill (J.O.C.); Duke Heart Center, Division of Clinical Pharmacology, Duke University Medical Center, Durham, NC (C.M.O.); Case Western Reserve University, Cleveland, Ohio (I.L.P.); Medical University, Faculty of Health Sciences, Clinical Military Hospital, Poland (P.P.); Department of Medicine, Henry Ford Hospital, Detroit, Mich (H.N.S.); University of California, San Francisco, and Veterans Affairs Medical Center, San Francisco, Calif (J.R.T.); Division of Cardiology, Tufts Medical Center, Boston, Mass (J.E.U.); Baylor Heart and Vascular Institute, Dallas, Tex (C.W.Y.); CHU Cardiology Department, Nancy University, Nancy, France (F.Z.); and Department of Medicine, Center Cardiovascular Quality and Outcomes, Northwestern University, Feinberg School of Medicine, Chicago, Ill (M.G.). , Sadiya KhanSadiya Khan From the Duke Clinical Research Institute Durham, NC (G.M.F.); Department of Emergency Medicine, Center for Cardiovascular Quality and Outcomes, Northwestern University, Feinberg School of Medicine, Chicago, Ill (P.S.P.); Departments of Medicine and Radiology, School of Medicine, University of North Carolina at Chapel Hill, NC (K.F.A.); Department of Cardiology, Castle Hill Hospital, University of Hull, Kingston-upon-Hull, UK (J.G.F.C.); Momentum Research Inc, Durham, NC (G.C.); Stavanger University Hospital, Stavanger, Norway; Institute of Internal Medicine, University of Bergen, Bergen, Norway (K.D.); Athens University Hospital Attikon, Athens, Greece (G.S.F.); Ahmanson-UCLA Cardiomyopathy Center, David Geffen UCLA Medical Center, Los Angeles, Calif (G.C.F.); University of California, San Diego, San Diego, Calif (B.G.); Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Ill (S.K.); Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC (A.F.H.); University Pierre et Marie Curie Paris, Assistance Publique Hopitaux de Paris, Paris, France (M.K.); Cardiovascular Center, Tufts Medical Center, and Tufts University School of Medicine, Boston, Mass (M.A.K.); Institute of Circulatory and Respiratory Health, Canadian Institutes of Health, Toronto General Hospital, University of Toronto (P.P.L.); ANMCO Research Center, Firenze, Italy (A.P.M.); University of California, San Francisco, Calif, Cardiology Division, San Francisco Veterans Affairs Medical Center, San Francisco, Calif (B.M.M.); BHF Cardiovascular Research Centre, University of Glas