Portal de Periódicos da CAPES

Mechanisms of Antibacterial Activity of MgO: Non‐ROS Mediated Toxicity of MgO Nanoparticles Towards Escherichia coli

2013; Wiley; Volume: 10; Issue: 6 Linguagem: Inglês

10.1002/smll.201302434

1613-6829

Yu Hang Leung, Alan Man Ching Ng, Xiaoying Xu, Zhiyong Shen, Lee A. Gethings, Mabel Ting Wong, Charis M.N. Chan, Mu Yao Guo, Yip Hang Ng, Aleksandra B. Djurišić, Patrick K. H. Lee, Wai Kin Chan, Li Yu, David Lee Phillips, P. Y. Angel, Frederick C. Leung,

Nanoparticle-Based Drug Delivery

The toxicity of metal oxide nanomaterials and their antimicrobial activity is attracting increasing attention. Among these materials, MgO is particularly interesting as a low cost, environmentally‐friendly material. The toxicity of MgO, similar to other metal oxide nanomaterials, is commonly attributed to the production of reactive oxygen species (ROS). We investigated the toxicity of three different MgO nanoparticle samples, and clearly demonstrated robust toxicity towards Escherichia coli bacterial cells in the absence of ROS production for two MgO nanoparticle samples. Proteomics data also clearly demonstrate the absence of oxidative stress and indicate that the primary mechanism of cell death is related to the cell membrane damage, which does not appear to be due to lipid peroxidation.