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Treatment of Oral Florid Papillomatosis With Bleomycin

1978; American Medical Association; Volume: 114; Issue: 7 Linguagem: Inglês

10.1001/archderm.1978.01640190067026

1538-3652

Manfred Hagedorn,

Cancer Diagnosis and Treatment

Oral florid papillomatosis was first recognized as a distinct disease by Rock and Fisher in 1960. 1 The choice of therapy for this rare disease is complicated by its unknown etiology and poorly defined state of malignancy. The only drugs that have shown any promise of success have been cytostatic agents. 2 The main purpose of this paper is to point out the possibility of using an intra-arterial ventricle catheter to achieve high tissue concentrations of bleomycin sulfate at the site of oral florid papillomatosis and thereby extirpate the neoplasm. Report of a Case The patient experienced the first occurrence of multiple verrucose lesions in the area of the buccal mucosa 12 years ago when he was 35 years of age. Despite intensive conservative measures and extensive surgery, the lesions remained and eventually spread to nearly the entire mucous membrane of the cheeks and lips, predominantly on the left side.