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PCA3 Score Before Radical Prostatectomy Predicts Extracapsular Extension and Tumor Volume

2008; Lippincott Williams & Wilkins; Volume: 180; Issue: 5 Linguagem: Inglês

10.1016/j.juro.2008.07.060

1527-3792

Eric J. Whitman, Jack Groskopf, Amina Ali, Yongmei Chen, Amy Blase, Bungo Furusato, György Petrovics, Mona Abdel-Halim Ibrahim, Sally Elsamanoudi, Jennifer Cullen, Isabell A. Sesterhenn, Stephen A. Brassell, Harry G. Rittenhouse, Shiv Srivastava, David G. McLeod,

Renal cell carcinoma treatment

No AccessJournal of UrologyAdult Urology1 Nov 2008PCA3 Score Before Radical Prostatectomy Predicts Extracapsular Extension and Tumor Volumeis accompanied byThe Significance of Monoamine Oxidase-A Expression in High Grade Prostate Cancer Eric J. Whitman, Jack Groskopf, Amina Ali, Yongmei Chen, Amy Blase, Bungo Furusato, Gyorgy Petrovics, Mona Ibrahim, Sally Elsamanoudi, Jennifer Cullen, Isabell A. Sesterhenn, Stephen Brassell, Harry Rittenhouse, Shiv Srivastava, and David G. McLeod Eric J. WhitmanEric J. Whitman , Jack GroskopfJack Groskopf , Amina AliAmina Ali , Yongmei ChenYongmei Chen , Amy BlaseAmy Blase , Bungo FurusatoBungo Furusato , Gyorgy PetrovicsGyorgy Petrovics , Mona IbrahimMona Ibrahim , Sally ElsamanoudiSally Elsamanoudi , Jennifer CullenJennifer Cullen , Isabell A. SesterhennIsabell A. Sesterhenn , Stephen BrassellStephen Brassell , Harry RittenhouseHarry Rittenhouse , Shiv SrivastavaShiv Srivastava , and David G. McLeodDavid G. McLeod View All Author Informationhttps://doi.org/10.1016/j.juro.2008.07.060AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: PCA3 is a prostate specific, nonprotein coding RNA that is over expressed in prostate cancer. Recent studies showed the diagnostic potential of a urine based PCA3 for predicting biopsy outcome. We assessed the relationship between urine PCA3 and pathological features in whole mount radical prostatectomy specimens. Materials and Methods: Post-digital rectal examination urine specimens were obtained from 72 men with prostate cancer before radical prostatectomy. PCA3 and PSA mRNA were measured. The ratio of PCA3 to PSA mRNA was recorded as a PCA3 score and correlated with data on each prostate specimen. Results: Patients with extracapsular extension had a significantly higher median PCA3 score than patients without extracapsular extension (48.8 vs 18.7, p = 0.02). PCA3 score significantly correlated with total tumor volume (r = 0.38, p <0.01). On multivariate analysis PCA3 score was an independent predictor of extracapsular extension (p = 0.01) and total tumor volume less than 0.5 cc (p = 0.04). At a cutoff PCA3 score of 47 extracapsular extension was predicted with 94% specificity and an 80% positive predictive value. When combined with serum PSA and biopsy Gleason score, the ROC AUC for predicting extracapsular extension was 0.90. Conclusions: PCA3 detected in the post-digital rectal examination urine of patients with prostate cancer correlated with pathological findings. Therefore, it could provide prognostic information. To our knowledge this is the first report of a molecular urine assay that predicts extracapsular extension. References 1 : Pretreatment nomogram for prostate-specific antigen recurrence after radical prostatectomy or external-beam radiation therapy for clinically localized prostate cancer. J Clin Oncol1999; 17: 168. Google Scholar 2 : Nomogram incorporating PSA level to predict cancer-specific survival for men with clinically localized prostate cancer managed without curative intent. Cancer2008; 112: 69. Google Scholar 3 : Updated nomogram to predict pathologic stage of prostate cancer given prostate-specific antigen level, clinical stage, and biopsy Gleason score (Partin tables) based on cases from 2000 to 2005. Urology2007; 69: 1095. Google Scholar 4 : Prostate cancer volume at biopsy predicts clinically significant upgrading. J Urol2008; 179: 896. Link, Google Scholar 5 : Correlation between prostate needle biopsy and radical prostatectomy Gleason gradings of 111 cases with prostatic adenocarcinoma. Urol J2004; 1: 246. Google Scholar 6 : Management and survival of screen-detected prostate cancer patients who might have been suitable for active surveillance. Eur Urol2006; 50: 475. Google Scholar 7 : Molecular detection of prostate cancer in urine by GSTP1 hypermethylation. Clin Cancer Res2001; 7: 2727. Google Scholar 8 : Is there a role for serum human tissue kallikrein in detection of prostate cancer?. Urology2007; 70: 519. Google Scholar 9 : Biomarkers for prostate cancer detection. J Urol2007; 178: 2252. Link, Google Scholar 10 : DD3(PCA3)-based molecular urine analysis for the diagnosis of prostate cancer. Eur Urol2003; 44: 8. Google Scholar 11 : PCA3: a molecular urine assay for predicting prostate biopsy outcome. J Urol2008; 179: 1587. Link, Google Scholar 12 : PCA3 molecular urine assay for prostate cancer in men undergoing repeat biopsy. Urology2007; 69: 532. Google Scholar 13 : Frequent overexpression of ETS-related gene-1 (ERG1) in prostate cancer transcriptome. Oncogene2005; 24: 3847. Google Scholar 14 : DD3: a new prostate-specific gene, highly overexpressed in prostate cancer. Cancer Res1999; 59: 5975. Google Scholar 15 : DD3(PCA3), a very sensitive and specific marker to detect prostate tumors. Cancer Res2002; 62: 2695. Google Scholar 16 : APTIMA PCA3 molecular urine test: development of a method to aid in the diagnosis of prostate cancer. Clin Chem2006; 52: 1089. Google Scholar 17 : PCA3 molecular urine assay correlates with prostate cancer tumor volume: implication in selecting candidates for active surveillance. J Urol2008; 179: 1804. Link, Google Scholar 18 : Mapping of TMPRSS2-ERG fusions in the context of multi-focal prostate cancer. Mod Pathol2008; 21: 67. Google Scholar 19 : A streamlined three-dimensional volume estimation method accurately classifies prostate tumors by volume. Am J Surg Pathol2003; 27: 1291. Google Scholar 20 : Admixture mapping identifies 8q24 as a prostate cancer risk locus in African-American men. Proc Natl Acad Sci USA2006; 103: 14068. Google Scholar Urology Service, Walter Reed Army Medical Center (EJW, SB, DGM) and Department of Genito-Urinary Pathology, Armed Forces Institute of Pathology (IAS, BF), Washington, D. C., Center for Prostate Disease Research (EJW, AA, YC, BF, GP, MI, SE, JC, SS, DGM), Department of Surgery, Uniformed Services University (GP, SB, SS, DGM), Bethesda, Maryland, and Gen-Probe, Inc., San Diego, California© 2008 by American Urological AssociationFiguresReferencesRelatedDetailsCited byPloussard G and de la Taille A (2014) Does PCA3 Really Help Urologists?Urology Practice, VOL. 1, NO. 2, (57-61), Online publication date: 1-Jul-2014.Chevli K, Duff M, Walter P, Yu C, Capuder B, Elshafei A, Malczewski S, Kattan M and Jones J (2013) Urinary PCA3 as a Predictor of Prostate Cancer in a Cohort of 3,073 Men Undergoing Initial Prostate BiopsyJournal of Urology, VOL. 191, NO. 6, (1743-1748), Online publication date: 1-Jun-2014.Whelan C, Kawachi M, Smith D, Linehan J, Babilonia G, Mejia R, Wilson T and Smith S (2013) Expressed Prostatic Secretion Biomarkers Improve Stratification of NCCN Active Surveillance Candidates: Performance of Secretion Capacity and TMPRSS2:ERG ModelsJournal of Urology, VOL. 191, NO. 1, (220-226), Online publication date: 1-Jan-2014.Bradley L, Palomaki G, Gutman S, Samson D and Aronson N (2013) Comparative Effectiveness Review: Prostate Cancer Antigen 3 Testing for the Diagnosis and Management of Prostate CancerJournal of Urology, VOL. 190, NO. 2, (389-398), Online publication date: 1-Aug-2013.Gittelman M, Hertzman B, Bailen J, Williams T, Koziol I, Henderson R, Efros M, Bidair M and Ward J (2013) PCA3 Molecular Urine Test as a Predictor of Repeat Prostate Biopsy Outcome in Men with Previous Negative Biopsies: A Prospective Multicenter Clinical StudyJournal of Urology, VOL. 190, NO. 1, (64-69), Online publication date: 1-Jul-2013.Salagierski M and Schalken J (2012) Molecular Diagnosis of Prostate Cancer: PCA3 and TMPRSS2:ERG Gene FusionJournal of Urology, VOL. 187, NO. 3, (795-801), Online publication date: 1-Mar-2012.de la Taille A, Irani J, Graefen M, Chun F, de Reijke T, Kil P, Gontero P, Mottaz A and Haese A (2011) Clinical Evaluation of the PCA3 Assay in Guiding Initial Biopsy DecisionsJournal of Urology, VOL. 185, NO. 6, (2119-2125), Online publication date: 1-Jun-2011.Vlaeminck-Guillem V, Devonec M, Colombel M, Rodriguez-Lafrasse C, Decaussin-Petrucci M and Ruffion A (2011) Urinary PCA3 Score Predicts Prostate Cancer MultifocalityJournal of Urology, VOL. 185, NO. 4, (1234-1239), Online publication date: 1-Apr-2011.Aubin S, Reid J, Sarno M, Blase A, Aussie J, Rittenhouse H, Rittmaster R, Andriole G and Groskopf J (2010) PCA3 Molecular Urine Test for Predicting Repeat Prostate Biopsy Outcome in Populations at Risk: Validation in the Placebo Arm of the Dutasteride REDUCE TrialJournal of Urology, VOL. 184, NO. 5, (1947-1952), Online publication date: 1-Nov-2010.Tosoian J, Loeb S, Kettermann A, Landis P, Elliot D, Epstein J, Partin A, Carter H and Sokoll L (2009) Accuracy of PCA3 Measurement in Predicting Short-Term Biopsy Progression in an Active Surveillance ProgramJournal of Urology, VOL. 183, NO. 2, (534-538), Online publication date: 1-Feb-2010.Related articlesJournal of Urology22 Sep 2008The Significance of Monoamine Oxidase-A Expression in High Grade Prostate Cancer Volume 180Issue 5November 2008Page: 1975-1979 Advertisement Copyright & Permissions© 2008 by American Urological AssociationKeywordsgene expressiontumor marker, biologicalprostatic neoplasmsurineprostateMetricsAuthor Information Eric J. Whitman More articles by this author Jack Groskopf Financial interest and/or other relationship with Gen-Probe. More articles by this author Amina Ali More articles by this author Yongmei Chen More articles by this author Amy Blase Financial interest and/or other relationship with Gen-Probe. More articles by this author Bungo Furusato More articles by this author Gyorgy Petrovics Financial interest and/or other relationship with Gen-Probe. More articles by this author Mona Ibrahim More articles by this author Sally Elsamanoudi More articles by this author Jennifer Cullen More articles by this author Isabell A. Sesterhenn More articles by this author Stephen Brassell More articles by this author Harry Rittenhouse Financial interest and/or other relationship with Gen-Probe. More articles by this author Shiv Srivastava More articles by this author David G. McLeod More articles by this author Expand All Advertisement PDF downloadLoading ...