Prostaglandin F2α as a potent excitant of the parasympathetic postganglionic neurons of the dog salivary gland
1973; Elsevier BV; Volume: 13; Issue: 5 Linguagem: Inglês
10.1016/0024-3205(73)90042-8
ISSN1879-0631
Autores Tópico(s)Receptor Mechanisms and Signaling
ResumoProstaglandin F2α (PGF2α) (1–100 ng) and acetylcholine (ACh) (0.3–30 μg) injected selectively into the artery supplying the submaxillary gland of the dog produced salivation and an increase in blood flow. Both salivary and vascular responses to PGF2α developed slowly and lasted long as compared with those to ACh. On a weight basis PGF2α was about 1000 times more potent than ACh in producing salivation. Upon repeated injections of PGF2α most glands developed moderate desensitization to PGF2α but not to ACh. Both salivary and vascular responses to PGF2α were abolished by infusion of tetrodotoxin ( or 0.1 or 0.2 μg/min), whereas those to ACh remained virtually unchanged. These results indicate that in the dog submaxillary gland PGF2α causes salivation and vasodilation exclusively through excitation of the parasympathetic postganglionic neurons.
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