Nuclear DNA content of occult sclerosing and frank papillary carcinoma of the thyroid
1971; Wiley; Volume: 27; Issue: 4 Linguagem: Inglês
10.1002/1097-0142(197104)27
ISSN1097-0142
AutoresM Izuo, Takashi Okagaki, Ralph M. Richart, Raffaele Lattes,
Tópico(s)Genetic factors in colorectal cancer
ResumoThe nuclear DNA content was measured in 6 cases of so-called occult sclerosing papillary carcinoma of the thyroid, 5 cases of frank (clinically detectable) papillary carcinoma, and one borderline atypical papillary lesion. One hundred neoplastic cell nuclei were measured in each case. Most of the cases in both groups of papillary carcinoma had a nuclear DNA distribution with a stem-line in the near-diploid region. After correcting to normality by logarithmic transformation and adjusting for S-phase cells, the "corrected computed modal values" in the majority of the cases were significantly hypodiploid. In 3 cases, correction for S phase cells was not applicable because the modes were not discrete. There was a widely spread aneuploid DNA distribution.
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