Portal de Periódicos da CAPES

Understanding the Consequences of Transfusion-Related Acute Lung Injury

2005; Elsevier BV; Volume: 128; Issue: 5 Linguagem: Inglês

10.1378/chest.128.5_suppl_2.598s

1931-3543

Aryeh Shander, Mark A. Popovsky,

Hemoglobin structure and function

Although the blood supply has become safer with regard to transmission of infectious agents, attention should continue to focus on understanding and eliminating the other serious risks associated with transfusion. Transfusion-related acute lung injury (TRALI) is one such risk, only recently becoming recognized as an important and potentially preventable clinical syndrome. Strategies for prevention of TRALI, however, must rely on knowledge regarding its etiology and diagnosis, and significant gaps in our understanding of the syndrome currently exist. This review summarizes what is known and unknown about the incidence, severity, etiology, diagnosis, and prevention of TRALI and the potential consequences of these knowledge gaps. Learning Objectives 1. To review the incidence and current theories regarding the pathogenesis of transfusion-related acute lung injury. 2. To understand the rationale and consequences of donor deferrals as a means to prevent transfusion-related acute lung injury. Although the blood supply has become safer with regard to transmission of infectious agents, attention should continue to focus on understanding and eliminating the other serious risks associated with transfusion. Transfusion-related acute lung injury (TRALI) is one such risk, only recently becoming recognized as an important and potentially preventable clinical syndrome. Strategies for prevention of TRALI, however, must rely on knowledge regarding its etiology and diagnosis, and significant gaps in our understanding of the syndrome currently exist. This review summarizes what is known and unknown about the incidence, severity, etiology, diagnosis, and prevention of TRALI and the potential consequences of these knowledge gaps. 1. To review the incidence and current theories regarding the pathogenesis of transfusion-related acute lung injury. 2. To understand the rationale and consequences of donor deferrals as a means to prevent transfusion-related acute lung injury.