Identifying and addressing unmet clinical needs in Ph-neg classical myeloproliferative neoplasms: A consensus-based SIE, SIES, GITMO position paper
2013; Elsevier BV; Volume: 38; Issue: 2 Linguagem: Inglês
10.1016/j.leukres.2013.09.008
ISSN1873-5835
AutoresGiovanni Barosi, Alessandro M. Vannucchi, Valerio De Stefano, Fabrizio Pane, Francesco Passamonti, Alessandro Rambaldi, Giuseppe Saglio, Tiziano Barbui, S Tura,
Tópico(s)Eosinophilic Disorders and Syndromes
ResumoThis article presents the results of group discussion among experts from SIE, SIES and GITMO societies aimed at highlighting unmet challenges in the management of Ph-neg myeloproliferative neoplasms (MPNs). The issues analyzed were: diagnosis of prefibrotic myelofibrosis; diagnosis of Ph-neg MPNs in the setting of splanchnic vein thrombosis (SVT); management of low-risk PV and low-risk ET patients with JAK2V617F mutation; molecular biomarkers in the prognostic evaluation of myelofibrosis (MF); ruxolitinib therapy in low-risk MF; therapy in patients with SVT-associated Ph-neg MPN; indications of splenectomy in MF. For each of these issues, proposals for advancement in clinical research were addressed.
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