Portal de Periódicos da CAPES

Steroidal saponins from the rhizomes of Smilax sieboldii

1992; Elsevier BV; Volume: 31; Issue: 7 Linguagem: Inglês

10.1016/0031-9422(92)83296-b

1873-3700

Tamotsu Nikaido, Taichi Ohmoto, Satoshi Kubo, Yoshihiro Mimaki, Yutaka Sashida,

Polysaccharides and Plant Cell Walls

Six new steroidal saponins were isolated from the rhizomes of Smilax sieboldii. Their structures were determined by spectroscopic analysis and hydrolysis to be 3β-hydroxy-(25R)-5α-spirostan-6-one (laxogenin)3-O-β-d-glucopyranosyl-(1 → 4)-O-[α-l-arabinopyranosyl-(1 → 6)]-β-d-glucopyranoside, laxogenin 3-O-α-l-arabinopyranosyl (1 → 6) -β-d-glucopyranoside,3β,27-dihydroxy-(25S)-5α-spirostan-6-one 3-O-β-d-glucopyranosyl-(1 →4 -O-[α-l-arabinopyranosyl-( 1 → 6) )-α-d-glucopyranoside, 26-O-β-d-glucopyranosyl-3β,22ξ,26-trihydroxy-(25R)-5α-furostan-6-one 3-O-α-l-arabinopyranosyl-(1 ar 6)-β-d-glucopyranoside, 26-O-β-d-glucopyranosyl-3β,22ξ,26-trihydroxy-(25R-5α-furostan-6-one 3-O-β-d-glucopyranosyl-(1 → 4)-O-[α-l-arabinopyranosyl-(1 ar 6)]-β-d-glucopyranoside and (25R)-5α-spirostan-3β-ol (tigogenin) 3-O-β-d-glucopyranosyl-(1 → 4)-O-[α-l-arabinopyranosyl-(1 → 6)]-β-d-glucopyranoside. The inhibition of cAMP phosphodiesterase by the saponins was evaluated.