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Iridoids As Allelochemicals and DNA Polymerase Inhibitors ⊥

2004; American Chemical Society; Volume: 67; Issue: 3 Linguagem: Inglês

10.1021/np030238b

1520-6025

Carlos R. Pungitore, Maximiliano Juri Ayub, Matías García, Eduardo J. Borkowski, Marta E. Sosa, Gladys M. Ciuffo, Óscar S. Giordano, Carlos E. Tonn,

Essential Oils and Antimicrobial Activity

Growth inhibitory activities and nutritional indices of catalpol (1), 8-O-acetylharpagide (2), and harpagide (3) were determinated in larvae and adults of Tribolium castaneum, respectively. Compound 1 produced a series of allelochemical effects probably related with the DNA synthesis. This iridoid possessed the highest inhibitory activity against DNA polymerase. Molecular orbital calculations suggest that a π−π charge transfer recognition model could explain the action of iridioids toward nucleic acid synthesis.