Single- and Multistep Resistance Selection Studies on the Activity of Retapamulin Compared to Other Agents against Staphylococcus aureus and Streptococcus pyogenes
2006; American Society for Microbiology; Volume: 50; Issue: 2 Linguagem: Inglês
10.1128/aac.50.2.765-769.2006
ISSN1098-6596
AutoresKlaudia Kosowska-Shick, Catherine Clark, Kim Credito, Pamela McGhee, Bonifacio Dewasse, Tatiana Bogdanovich, Peter C. Appelbaum,
Tópico(s)Plant Disease Resistance and Genetics
ResumoABSTRACT Retapamulin had the lowest rate of spontaneous mutations by single-step passaging and the lowest parent and selected mutant MICs by multistep passaging among all drugs tested for all Staphylococcus aureus strains and three Streptococcus pyogenes strains which yielded resistant clones. Retapamulin has a low potential for resistance selection in S. pyogenes , with a slow and gradual propensity for resistance development in S. aureus .
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