Portal de Periódicos da CAPES

Familial gastric polyposis revisited

1991; Elsevier BV; Volume: 53; Issue: 1 Linguagem: Inglês

10.1016/0165-4608(91)90119-f

1873-4456

Raquel Seruca, Fátima Carneiro, Sérgio Castedo, Leonor David, Carlos Lopes, Manuel Sobrinho‐Simões,

Helicobacter pylori-related gastroenterology studies

We update and review a large pedigree originally described by Santos and Magalhães with familial gastric polyposis and a high incidence of gastric cancer. The present observation of male-to-male transmission of the disease clearly demonstrates the autosomal dominant pattern of inheritance. The histologic review of the polyps present in several members of the family allowed the diagnosis of hyperplastic polyposis. Eight members of the family (two with concomitant gastric pathology) have severe cutaneous psoriasis. This finding may represent the existence of two different disorders segregating in the family or, alternatively, pleiotropic manifestations of the same gene.