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Physiological Role of Silent Receptors of Atrial Natriuretic Factor

1987; American Association for the Advancement of Science; Volume: 238; Issue: 4827 Linguagem: Inglês

10.1126/science.2823385

1095-9203

Thomas Maack, Muneya Suzuki, Fernando Antônio de Almeida, Daniel R. Nussenzveig, Robert M. Scarborough, Glenn McEnroe, John Lewicki,

Atrial Fibrillation Management and Outcomes

A ring-deleted analog of atrial natriuretic factor—des[Gln 18 , Ser 19 , Gly 20 , Leu 21 , Gly 22 ] ANF 4-23 -NH 2 (C-ANF 4-23 )—binds with high affinity to approximately 99% of ANF receptors in the isolated perfused rat kidney. In this preparation, C-ANF 4-23 is devoid of detectable renal effects and does not antagonize any of the known renal hemodynamic and natriuretic actions of biologically active ANF 1-28 . In contrast, both C-ANF 4-23 and ANF 1-28 increase sodium excretion and decrease blood pressure in intact anesthetized rats. This apparent contradiction is resolved by the finding that the ring-deleted analog markedly increases plasma levels of endogenous immunoreactive ANF in the rat. The results show that the majority of the renal receptors of ANF are biologically silent. This new class of receptors may serve as specific peripheral storage-clearance binding sites, acting as a hormonal buffer system to modulate plasma levels of ANF.