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Danazol and stanozolol in long-term prophylactic treatment of hereditary angioedema

1980; Elsevier BV; Volume: 65; Issue: 1 Linguagem: Inglês

10.1016/0091-6749(80)90181-5

1097-6825

A Agostoni, Marco Cicardi, G. Martignoni, Luigi Bergamaschini, Bianca Marasini,

Steroid Chemistry and Biochemistry

Treatment with 17 alpha-methyltestosterone and with some synthetic androgens prevents attacks of hereditary angioedema (HAE). However, the potential hepatotoxicity of 17 alpha-alkylated androgens raises the problem of long-term prophylactic use of these agents. Therefore we compared the efficacy in preventing HAE attacks of 17 alpha-alkylated steroids (danazol and stanozolol) with non-17 alpha-alkylated derivatives (quinbolone, nandrolone decanoate and mesterolone). As the latter group proved ineffective, it seems that a drug's efficacy in preventing HAE attacks is connected to its 17 alpha-alkylation. Moreover, our long-term observations with the minimum effective dose of danazol seem to indicate the absence of important collateral effects.