The interaction of phosphine with haemoglobin and erythrocytes
1992; Taylor & Francis; Volume: 22; Issue: 5 Linguagem: Inglês
10.3109/00498259209053123
ISSN1366-5928
AutoresKen Lee Chin, Xianghua Mai, Jean Meaklim, Geoffrey R. Scollary, D. D. Leaver,
Tópico(s)Metabolism and Genetic Disorders
Resumo1. Phosphine progressively converts oxyhaemoglobin to methaemoglobin and hemichrome species, with the product formed being time- and concentration-dependent.2. The reaction of phosphine with oxyhaemoglobin leads to the formation of phosphite and phosphate.3. Incubation of rat erythrocytes with various concentrations of phosphine results in the progressive uptake of phosphine by the erythrocytes in a temperature-dependent first-order process.4. Uptake of phosphine by erythrocytes causes crenation, but conversion of oxyhaemoglobin to methaemoglobin and hemichrome could not be demonstrated.
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