Tissue oxygen sensor function of NADPH oxidase isoforms, an unusual cytochrome aa3 and reactive oxygen species
2001; Elsevier BV; Volume: 128; Issue: 3 Linguagem: Inglês
10.1016/s0034-5687(01)00310-3
ISSN1872-7611
AutoresTorsten Porwol, Wilhelm Ehleben, Verena Brand, H. Acker,
Tópico(s)Photoreceptor and optogenetics research
ResumoNADPH oxidase isoforms with different gp91phox subunits as well as an unusual cytochrome aa3 with a heme a/a3 relationship of 9:91 are discussed as putative oxygen sensor proteins influencing gene expression and ion channel conductivity. Reactive oxygen species (ROS) are important second messengers of the oxygen sensing signal cascade determining the stability of transcription factors or the gating of ion channels. The formation of ROS by a perinuclear Fenton reaction is imaged by 1 and 2 photon confocal microscopy revealing mitochondrial and non-mitochondrial generation.
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