Portal de Periódicos da CAPES

Elastosis in breast cancer

1974; Wiley; Volume: 33; Issue: 1 Linguagem: Inglês

10.1002/1097-0142(197401)33

1097-0142

J. G. Azzopardi, Ricardo Laurini,

Bone health and osteoporosis research

CancerVolume 33, Issue 1 p. 174-183 ArticleFree Access Elastosis in breast cancer Dr. J. G. Azzopardi MD, MRCPath, Corresponding Author Dr. J. G. Azzopardi MD, MRCPath Department of Histopathology, Royal Postgraduate Medical School, London, England Reader in Oncology.Department of Histopathology, Royal Postgraduate Medical School, Ducane Road, London W.12, England===Search for more papers by this authorR. N. Laurini MD, R. N. Laurini MD Department of Histopathology, Royal Postgraduate Medical School, London, England Registrar in Histopathology.Search for more papers by this author Dr. J. G. Azzopardi MD, MRCPath, Corresponding Author Dr. J. G. Azzopardi MD, MRCPath Department of Histopathology, Royal Postgraduate Medical School, London, England Reader in Oncology.Department of Histopathology, Royal Postgraduate Medical School, Ducane Road, London W.12, England===Search for more papers by this authorR. N. Laurini MD, R. N. Laurini MD Department of Histopathology, Royal Postgraduate Medical School, London, England Registrar in Histopathology.Search for more papers by this author First published: January 1974 https://doi.org/10.1002/1097-0142(197401)33:1 3.0.CO;2-XCitations: 71 AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat Abstract The yellow streaks seen in scirrhous carcinoma of the breast are not the result of necrosis, as is usually stated. They consist of elastic tissue. Elastosis occurs in about 90% of scirrhous and infiltrating lobular carcinomas. Elastosis is a much less prominent feature of medullary carcinoma and the other "specialized" types of breast cancer. Focal elastosis is found mainly periductally and in vascular walls. Vascular elastosis affects veins preferentially. Diffuse elastosis often accompanies the focal varieties. Elastosis is thought to be mainly the result of factors emanating from infiltrating carcinoma cells. These factors stimulate fibroblasts and possibly other cells to produce elastic tissue. Elastosis accompanying duct carcinoma is usually an indicator of early infiltration. Elastosis, in the absence of overt signs of malignancy, needs careful appraisal. The diagnostic significance of elastosis is discussed. Its biological significance in breast cancer is a challenging problem awaiting solution. References 1 Azzopardi, J. G., and Zayid, I.: Elastic tissue in tumors of salivary glands. J. Pathol. 107: 149–156, 1972. 10.1002/path.1711070302 CASPubMedWeb of Science®Google Scholar 2 Beattie, J. M., and Dickson, W. E. C.: A Textbook of Special Pathology, 3rd ed. London, William Heinemann, Ltd., 1926. Google Scholar 3 Bernath, Cabriella.: Amyloidosis in malignant tumors. Acta. Morphol. 2: 137–144, 1952. Google Scholar 4 Bonser, G. M., Dossett, J. A., and Jull, J. W.: Human and Experimental Breast Cancer, London, Pitman Medical Publishing Co., Ltd., 1961. Google Scholar 5 Cheatle, Sir G. L., and Cutler, M.: Tumors of the Breast—Their Pathology, Symptoms, Diagnosis and Treatment, London, Edward Arnold & Co., 1931. Google Scholar 6 Hamperl, H.: Zur Kenntnis des sog—Carcinoma lobulare in situ der Mamma. Z. Krebsforsch. 77: 231–246, 1972. 10.1007/BF02570689 CASPubMedWeb of Science®Google Scholar 7 Jackson, J. G., and Orr, J. W.: The ducts of carcinomatous breasts, with particular reference to connective-tissue changes. J. Pathol. Bacterial. 74: 265–273, 1957. 10.1002/path.1700740203 CASWeb of Science®Google Scholar 8 Lundmark, C.: Breast cancer and elastosis. Cancer 30: 1195–1201, 1972. 10.1002/1097-0142(197211)30:5 3.0.CO;2-H CASPubMedWeb of Science®Google Scholar 9 Muir, R., and Aitkenhead, Anne C.: The healing of intra-duct carcinoma of the mamma. J. Pathol. Bacteriol. 38: 117–127, 1934. 10.1002/path.1700380202 Web of Science®Google Scholar 10 Murad, T. M., and Scarpelli, D. G.: The ultra-structure of medullary and scirrhous mammary duct carcinoma. Am. J. Pathol. 50: 335–360, 1967. CASPubMedWeb of Science®Google Scholar Citing Literature Volume33, Issue1January 1974Pages 174-183 ReferencesRelatedInformation