Artigo Acesso aberto Revisado por pares

Intravenous Immunoglobulin as a Treatment for BK Virus Associated Nephropathy: One-Year Follow-Up of Renal Allograft Recipients

2006; Wolters Kluwer; Volume: 81; Issue: 1 Linguagem: Inglês

10.1097/01.tp.0000181096.14257.c2

ISSN

1534-6080

Autores

Alp Şener, Andrew A. House, Anthony M. Jevnikar, Neil Boudville, Vivian C. McAlister, Norman Muirhead, Faisal Rehman, Patrick Luke,

Tópico(s)

Polyomavirus and related diseases

Resumo

BK virus associated nephropathy (BKVAN) has emerged as an important cause of renal allograft dysfunction and graft loss. Although several treatment strategies have been proposed, the rate of graft loss remains high. We studied the outcome of renal transplant patients with BKVAN treated with IVIG. After 11.4±3.9 months (mean±SEM) from the time of transplantation, 8 renal allograft recipients were diagnosed with BKVAN. In addition to a reduction of immunosuppressive therapy, patients received 2 g/kg IVIG. After a mean follow-up of 15 months, all except one patient are currently off dialysis. In summary, after IVIG therapy, 88% of patients still have functioning grafts, although renal function continues to be impaired. The benefit of concomitant IVIG and reduction of immunosuppressive therapy in BKVAN needs to be further addressed in randomized, multicentered trials.

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