Lymphocyte subpopulations among pregnant women in Agbor, Delta State, Nigeria
2012; Asian Pacific Journal of Tropical Disease Editorial Office; Volume: 2; Issue: 4 Linguagem: Inglês
10.1016/s2222-1808(12)60064-4
ISSN2222-1808
AutoresE. A. Ophori, Clement Ndudi Isibor,
Tópico(s)COVID-19 Impact on Reproduction
ResumoTo determine the peripheral blood CD3 and CD8 T-lymphocytes subpopulation in healthy pregnant women in our environment. Pregnant women attending the antenatal care clinic (ANC) of the Central Hospital, Agbor, Nigeria, who gave informed consent were recruited for the study. Blood samples (10 mL) was collected by venipuncture from 121 healthy pregnant women (aged 17-47 years; mean 28.5±0.43). Tweenty four non-pregnant healthy women (aged 18-30years; mean 21.12±0.64) were enrolled as control. CD3+ and CD8+ counts were determined with the Partec flow cytometer. The mean CD3+ count for pregnant women was 1311.10±71.50 μ/L when compared to the controls which was 9.67±0.99 μ/L. This was statistically significant(P 0.005). Primigravidas had a higher CD3+ mean count than multiparas while mean CD8+ count was higher in multiparas than in primigravidas. Similarly, the mean CD3+ count was significantly different between all the trimesters with the highest count of 1, 353.23±43.90 μ/L in the first trimester as compared to the 9.67±0.99 μ/L in the control. Mean CD3+ was highly significant in pregnant women with history of previous abortions while the CD8+ cells were not. The results suggest the need for routine determination of T lymphocyte subsets apart from CD4 in pregnant women attending ANC clinic to prevent any possible immunological /pregnancy disorder during the period of pregnancy.
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