Portal de Periódicos da CAPES

Behavioral Effects of Cytokines: An Insight into Mechanisms of Sickness Behavior

1993; Elsevier BV; Linguagem: Inglês

10.1016/s1043-9471(13)70013-2

1043-9471

Robert Dantzer, Rose-Marie Bluthé, Stephen Kent, Glyn Goodall,

Circadian rhythm and melatonin

This chapter provides an overview of behavioral effects of cytokines. Pyrogenic cytokines are somnogenic and induce lethargia, behavioral depression, and anorexia. Although interleukin-1 (IL-1) and tumor necrosis factor (TNF) share many biological properties, they do not necessarily induce the same experience of sickness. Proinflammatory cytokines decrease general activity. In general, peripheral and central injections of cytokines induce the same range of behavioral effects. Chronic administration of rhIL-1β via a subcutaneously implanted osmotic mini pump results in the development of tolerance to the anorexic and weight-depressing effects of IL-1 within a few days. Cytokines have the ability to induce the synthesis and release of other cytokines and themselves in a cascade-dependent manner. This cascade serves to amplify the local effects of cytokines into a global effect due to multiplicity of targets and the overlapping biological effects of cytokines. IL-1 and other proinflammatory cytokines can significantly interfere with spontaneous or acquired behavior by their action on several peripheral cellular targets.