Linearity of Pharmacokinetics and Model Estimation of Sufentanil
1995; Lippincott Williams & Wilkins; Volume: 83; Issue: 6 Linguagem: Inglês
10.1097/00000542-199512000-00010
ISSN1528-1175
AutoresE. Gepts, Steven L. Shafer, Frédéric Camu, Donald R. Stanski, Robert Woestenborghs, Achiel Van Peer, J. Heykants,
Tópico(s)Anesthesia and Pain Management
ResumoAbstract Background The pharmacokinetic profiles of sufentanil available in the literature are conflicting because of methodologic differences. Length of sampling and assay sensitivity are key factors involved in accurately estimating the volumes of distribution, clearances, and elimination phase. The unit disposition function of increasing doses of sufentanil were investigated and the influence of dose administered on the linearity of pharmacokinetics was assessed.
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