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Blockade of the behavioral effects of 5-HTP by the decarboxylase inhibitor Ro 4-4602

1976; Elsevier BV; Volume: 4; Issue: 4 Linguagem: Inglês

10.1016/0091-3057(76)90056-3

1873-5177

Richard B. Carter, James B. Appel,

Behavioral and Psychological Studies

Twenty male rats were trained to press a bar on a fixed-ratio (FR 32) schedule of water reinforcement. The behavioral effects of 5-HTP (50 mg/kg) were studied following pretreatment with small (50 mg/kg) and large (400 mg/kg) doses of the decarboxylase inhibitor Ro 4-4602. It was found that both doses of the pretreatment agent blocked the disruptive effects of 5-HTP. This result suggests that at least some of the effects of 5-HTP may be mediated peripherally.