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Role of nuclear factor-κ B in melanoma

2005; Springer Science+Business Media; Volume: 24; Issue: 2 Linguagem: Inglês

10.1007/s10555-005-1579-7

1573-7233

Katayoun I. Amiri, Ann Richmond,

Cytokine Signaling Pathways and Interactions

Nuclear Factor-kappa B (NF-κ B) is an inducible transcription factor that regulates the expression of many genes involved in the immune response. Recently, NF-κ B activity has been shown to be upregulated in many cancers, including melanoma. Data indicate that the enhanced activation of NF-κ B may be due to deregulations in upstream signaling pathways such as Ras/Raf, PI3K/Akt, and NIK. Multiple studies have shown that NF-κ B is involved in the regulation of apoptosis, angiogenesis, and tumor cell invasion, all of which indicate the important role of NF-κ B in tumorigenesis. Thus, understanding the molecular mechanism of melanoma progression will aid in designing new therapeutic approaches for melanoma. In this review, the association between NF-κ B and melanoma tumorigenesis are discussed. Additionally, the potential of emerging selective NF-κ B inhibitors for the treatment of melanoma is reviewed.