Regioselective functionalization of 3-oxygenated estra-1,3,5(10)-trienes AT C-1 VIA (η6-arene)Cr(CO)3 complexes
1988; Elsevier BV; Volume: 29; Issue: 26 Linguagem: Inglês
10.1016/0040-4039(88)85127-x
ISSN1873-3581
AutoresHermann Künzer, Manfred Thiel,
Tópico(s)Organometallic Complex Synthesis and Catalysis
ResumoThe nucleophilic addition - oxidation reaction between the lithium anion of 1,3-dithiane and a mixture of complexes 3 and 4 installs the heterocycle predominantly at C-1 of the steroid to afford 5. This intermediate is converted into C-1 substituted steroids 6–12.
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