Polyunsaturated phosphatidylcholine and lipolysis: Metabolic interactions in vitro and in vivo
1977; Elsevier BV; Volume: 20; Issue: 6 Linguagem: Inglês
10.1016/0024-3205(77)90282-x
ISSN1879-0631
AutoresMarco Prosdocimi, Laura Caparrotta, K Szyszka,
Tópico(s)Lipid metabolism and biosynthesis
ResumoPolyunsaturated phosphatidylcholine (EPL) is known to have a number of effects on lipid metabolism. We tested the drug on rat adipose tissue in vitro: stimulated lipolysis was inhibited without any effect on cyclic AMP level. Administration of EPL in rats enhanced the basal lipolysis and inhibited the hormone stimulated process. In fasting rats, the high plasma FFA level was further increased by EPL, while no modification on total esterified fatty acids, glucose and cholesterol contents was found. These effects could be due to the activity of EPL on various enzymes, for instance lipoprotein lipase, or to a general effect on membranes.
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