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Nitric oxide: from discovery to the clinic

1998; Elsevier BV; Volume: 19; Issue: 11 Linguagem: Inglês

10.1016/s0165-6147(98)01265-6

1873-3735

Santiago Lamas, Dolores Pérez‐Sala, Salvador Moncada,

Eicosanoids and Hypertension Pharmacology

A little over a decade after its discovery, NO has proven beyond doubt to be a significant biological entity. Not only does it convey crucial signals that result in a wide spectrum of effects such as vasodilatation, modulation of neurotransmission and host defense in the immune response[1], but it is now clear that it acts as an important regulator of general cellular processes such as gene expression and mitochondrial function. A recent meeting4Nitric Oxide: From Discovery to the Clinic, Juan March Foundation, 22–24 June 1998, Madrid, Spain.4 addressed these issues, on the one hand updating novel findings in basic biology and on the other summarizing the status of the current and potential applicability of NO in the clinic.