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Association between prepregnancy body mass index and congenital heart defects

2009; Elsevier BV; Volume: 202; Issue: 1 Linguagem: Inglês

10.1016/j.ajog.2009.08.005

1097-6868

Suzanne M. Gilboa, Adolfo Correa, Lorenzo D. Botto, Sonja A. Rasmussen, D. Kim Waller, Charlotte A. Hobbs, Mario A. Cleves, Tiffany Riehle‐Colarusso,

Pregnancy and preeclampsia studies

Objective The purpose of this study was to examine associations between prepregnancy body mass index (BMI) and congenital heart defects (CHDs). Study Design These analyses included case infants with CHDs (n = 6440) and liveborn control infants without birth defects (n = 5673) enrolled in the National Birth Defects Prevention Study (1997-2004). Results Adjusted odds ratios for all CHDs combined were 1.16 (95% confidence interval [CI], 1.05–1.29), 1.15 (95% CI, 1.00–1.32), and 1.31 (95% CI, 1.11–1.56) for overweight status, moderate obesity, and severe obesity, respectively. Phenotypes associated with elevated BMI (≥25.0 kg/m2) were conotruncal defects (tetralogy of Fallot), total anomalous pulmonary venous return, hypoplastic left heart syndrome, right ventricular outflow tract (RVOT) defects (pulmonary valve stenosis), and septal defects (secundum atrial septal defect). Conclusion These results corroborated those of previous studies and suggested new associations between obesity and conotruncal defects and RVOT defects. The purpose of this study was to examine associations between prepregnancy body mass index (BMI) and congenital heart defects (CHDs). These analyses included case infants with CHDs (n = 6440) and liveborn control infants without birth defects (n = 5673) enrolled in the National Birth Defects Prevention Study (1997-2004). Adjusted odds ratios for all CHDs combined were 1.16 (95% confidence interval [CI], 1.05–1.29), 1.15 (95% CI, 1.00–1.32), and 1.31 (95% CI, 1.11–1.56) for overweight status, moderate obesity, and severe obesity, respectively. Phenotypes associated with elevated BMI (≥25.0 kg/m2) were conotruncal defects (tetralogy of Fallot), total anomalous pulmonary venous return, hypoplastic left heart syndrome, right ventricular outflow tract (RVOT) defects (pulmonary valve stenosis), and septal defects (secundum atrial septal defect). These results corroborated those of previous studies and suggested new associations between obesity and conotruncal defects and RVOT defects.