Surface modification of diamond-like carbon films with protein via polydopamine inspired coatings
2009; Elsevier BV; Volume: 256; Issue: 1 Linguagem: Inglês
10.1016/j.apsusc.2009.08.024
ISSN1873-5584
AutoresCaihong Tao, Shengrong Yang, Junyan Zhang, Jinqing Wang,
Tópico(s)Diamond and Carbon-based Materials Research
ResumoIn this paper, we report a facile two-step approach to immobilize proteins onto DLC surfaces. The first step was a simple immersion of DLC in a solution of dopamine. Polydopamine was deposited on DLC as a stable anchor to present protein molecules. Then the protein ad-layer was deposited on it. The chemical components of the modified DLC surfaces were characterized by Fourier transform infrared spectra and X-ray photoelectron spectroscopy. The biocompatibility of it was evaluated in vitro by the tetrazolium salt method. And it was indicated that the BSA modified surface had good haemocompatibility properties, and was cytocompatible to PC-12 cells.
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