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The Absorption of Calcium Carbonate

1967; American College of Physicians; Volume: 66; Issue: 5 Linguagem: Inglês

10.7326/0003-4819-66-5-917

1539-3704

Peter Ivanovich,

Sarcoma Diagnosis and Treatment

Article1 May 1967The Absorption of Calcium CarbonatePETER IVANOVICH, M.D., HAROLD FELLOWS, B.A., CLAYTON RICH, M.D.PETER IVANOVICH, M.D., HAROLD FELLOWS, B.A., CLAYTON RICH, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-66-5-917 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAlthough calcium carbonate (CaCO3) is widely used in the treatment of peptic ulcer disease and is freely available on the open market, relatively little information about its absorption is available. It has often been assumed that, because CaCO3is insoluble in water, calcium given in this form is not appreciably absorbed. However, significant hypercalcemia and alkalosis are observed occasionally among persons treated with CaCO3(1,2), and in a controlled study, hypercalcemia was found to be a frequent complication of this form of treatment (3). Furthermore, some patients treated with milk and alkali develop irreversible renal damage and calcifications of the...References1. COPE CL: Base changes in the alkalosis produced in the treatment of gastric ulcer with alkali. Clin. Sci. 2: 287, 1936. Google Scholar2. PUNSARSOMER ST: The milk-alkali syndrome. A report of three illustrative cases and a review of the literature. Acta Med. Scand. 173: 435, 1963. CrossrefMedlineGoogle Scholar3. MCMILLANFREEMAN DERB: The milk alkali syndrome: a study of the acute disorder with comments on the development of the chronic condition. Medicine (Balt.) 44: 485, 1965. CrossrefMedlineGoogle Scholar4. BURNETTCOMMONSALBRIGHTHOWARD CHRRFJE: Hypercalcemia without hypercalcuria or hypophosphatemia, calcinosis and renal insufficiency: a syndrome following prolonged intake of milk and alkali. New Eng. J. Med. 240: 787, 1949. CrossrefMedlineGoogle Scholar5. COPEBARNESCASTLEMANMUELLERROTH OBABGCSI: Vicissitudes of parathyroid surgery: trials of diagnosis and management in 51 patients with a variety of disorders. Ann. Surg. 154: 491, 1961. CrossrefMedlineGoogle Scholar6. DEGRAZIAIVANOVICHFELLOWSRICH JAPHC: A double isotope method for measurement of intestinal absorption of calcium in man. J. Lab. Clin. Med. 66: 822, 1965. MedlineGoogle Scholar7. DEGRAZIARICH JAC: Studies of intestinal absorption of calcium-45 in man. Metabolism 13: 650, 1964. CrossrefMedlineGoogle Scholar8. OTTENJANNWIDMAIERDEMLING RFL: Hypercalcämie und magensekretion. Klin. Wschr. 41: 717, 1963. CrossrefMedlineGoogle Scholar9. HEANEYWHEDON RPG: Radiocalcium studies of bone formation rate in human metabolic bone disease. J. Clin. Endocr. 18: 1246, 1958. CrossrefGoogle Scholar10. SKILLMANHEANEY TGRP: Endogenous intestinal calcium secretion (abstract). J. Lab. Clin. Med. 60: 1018, 1962. Google Scholar11. THOMASBIRDLEWIS WCEDAM: Effects of alkaline salt on distribution of Ca47 in hypoparathyroidism(abstract). Clin. Res. 14: 102, 1966. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Seattle, WashingtonFrom the University of Washington School of Medicine and the Radioisotope Service, Veterans Administration Hospital, Seattle, Wash.This study was supported in part by grants AM 09096 and AM 04701, U. S. Public Health Service, Washington, D. C.Requests for reprints should be addressed to Clayton Rich, M.D., Veterans Administration Hospital, 4435 Beacon Ave. South, Seattle, Wash. 98108. 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