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Octadecyl, Phenyl and Cyano Phases Comparison for the RP-HPLC Prediction of Octanol-Water Partition Coefficient

1987; Marcel Dekker; Volume: 10; Issue: 6 Linguagem: Inglês

10.1080/01483918708066754

2331-0413

Maria Chiara Pietrogrande, Francesco Dondi, G. Blo, Pier Andrea Borea, C. Bighi,

Metabolomics and Mass Spectrometry Studies

Abstract On phenyl and cyano phases log k' values were determined, for a series of benzodiazepines. The log k' values linearly extrapolated at 100% water were highly significantly correlated to log P values. A comparison with the most commonly used octadecyl phase demonstrates that phenyl is the best phase for log P prediction, cyano the most sensitive to the presence of particular moieties in the solute molecule, whereas octadecyl allows to obtain the most sensible measure of solute lipophylicity.