Portal de Periódicos da CAPES

GLP-1 (7 - 36) Amide: Effects on Glucose Transport and Metabolism in Rat Adipose Tissue

1997; Thieme Medical Publishers (Germany); Volume: 29; Issue: 09 Linguagem: Inglês

10.1055/s-2007-979068

1439-4286

Almudena Perea, Concepción Viñambres, F. Clemente, María Luisa Villanueva‐Peñacarrillo, Isabel Valverde,

Diabetes Treatment and Management

In rat adipocytes, GLP-1 (7-36) amide induced an increment in 2-deoxy-glucose uptake, which was additive to that of insulin. Furthermore, in rat fat, GLP-1 (7-36) amide provoked a rise in glycogen synthesis, glucose oxidation and utilization and lipogenesis, the increments being lower than those obtained with insulin. These data support the idea that GLP-1 exerts insulin-like effects on glucose metabolism in rat adipose tissue, as it does in rat hepatocytes and skeletal muscle, although with a lower potency than that of insulin.