Portal de Periódicos da CAPES

Oral versus intramuscular vitamin K in newborn infants.

1993; BMJ; Volume: 306; Issue: 6887 Linguagem: Inglês

10.1136/bmj.306.6887.1272-c

0959-8138

Jyoti Gupta, D Naidoo,

S100 Proteins and Annexins

have attempted to rule this out by repeated measurements of albumin excretion, but they present data from only 23 patients, less than 2% of the total population, who each contributed nine urine samples over an unspecified time period.The risk of misclassification on the basis of albumin excretion rates calculated from timed overnight urine collections seems much less.We have measured albumin excretion rate in overnight urine samples collected on two consecutive nights from 211 diabetic patients, 105 insulin dependent and 106 non-insulin dependent, mean age 55 (range 19-81) years and duration of diabetes 21 (8-51) years.This correlation coefficient of albumin excretion rate in the two samples was 0 95 (p<0001).In only seven cases (3-4%) was categorisation different between the two collec- tions, in all cases the change being from normo- albuminuria to microalbuminuria or vice versa (table ).Comparison of albumin excretion rate in overnight urine samples collected on consecutive nights from 211 diabetic patients.Values are numbers ofpatients Rate in Rate in first sample (pg/min) second sample 200 (pg/min) Normal Microalbuminuria Macroalbuminia 200 0 0 21Thus although we support the statement of Johnston and colleagues that no patient should be categorised on the basis of one measurement of albumin concentration or albumin:creatinine ratio in an early morning urine sample, we suggest that, after initial screening, formal classification should be done on the basis of albumin excretion rate measured in timed urine collections, when the day to day variability and hence the risk of misclassification seems much lower.