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Analysis of E2 amino acid variants of human papillomavirus types 16 and 18 and their associations with lesion grade and HLA DR/DQ type

1997; Wiley; Volume: 73; Issue: 5 Linguagem: Inglês

10.1002/(sici)1097-0215(19971127)73

1097-0215

George Terry, Linda Ho, Jack Cuzick,

T-cell and Retrovirus Studies

Human papillomavirus (HPV) 16 and HPV18 E2 amino acid variants and host HLA DR/DQ haplotypes have been identified by direct nucleic acid sequencing from cervical scrapes. HPV16 E2 variants co-segregate with a nucleotide variant at nt350 (in E6), which previously has been associated with persistent infections. Both HPV16 and HPV18 E2 variants occur relatively more frequently in individuals with HLA DR/DQ haplotypes 0401/0301 and 1101/0301 but are not related to lesion grade. Int. J. Cancer 73:651–655, 1997. © 1997 Wiley-Liss, Inc.