γ-Aminobutyric acid (GABAB) receptor-mediated inhibition of tyrosine hydroxylase activity in the striatum of rat
1991; Elsevier BV; Volume: 30; Issue: 10 Linguagem: Inglês
10.1016/0028-3908(91)90132-u
ISSN1873-7064
AutoresJosé‐Antonio Arias‐Montaño, Daniel Martínez‐Fong, Jorge Aceves,
Tópico(s)Biochemical effects in animals
ResumoThe effects of GABA and GABA agonists on calcium and depolarization-dependent stimulation of tyrosine hydroxylase activity in striatal slices were studied. gamma-Aminobutyric acid and (-)baclofen inhibited, while muscimol and (+)baclofen did not affect, the stimulation of tyrosine hydroxylase. The inhibitory effect of GABA and (-)baclofen was blocked by the GABAB antagonist, phaclofen but not by the GABAA antagonist, picrotoxin. The data suggest that the activity of tyrosine hydroxylase on dopaminergic nigrostriatal terminals may be modulated by GABA via GABAB receptors.
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