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Phylogenetic Analysis of Brazilian HIV Type 1 Subtype D Strains: Tracing the Origin of This Subtype in Brazil

2006; Mary Ann Liebert, Inc.; Volume: 22; Issue: 2 Linguagem: Inglês

10.1089/aid.2006.22.207

1931-8405

José Carlos Couto-Fernandez, Walter de Araújo Eyer-Silva, Monick Lindenmeyer Guimarães, Saada L. Chequer-Fernandez, Beatriz Grinsztejn, Éric Delaporte, Martine Peeters, Mariza Gonçalves Morgado,

HIV/AIDS Research and Interventions

HIV-1 Subtype D occurs mainly in East and Central African countries, especially Uganda, where the prevalence of HIV-1 infection is among the highest in the world. We present the phylogenetic analysis of one nonautochthonous and four autochthonous (including a near full-length genome) Brazilian HIV-1 subtype D strains identified in Rio de Janeiro State, where subtypes B, F1, and BF1 recombinants predominate. Phylogenetic inferences using maximum likelihood were applied on a near-full length genome and on concatenated gag, protease, reverse transcriptase, integrase, C2V3/env, gp41, and nef segments. Sequences from an Angolan immigrant showed close genetic similarity with a strain described in Finland, from an HIV patient of African origin, whereas all four autochthonous Brazilian sequences clustered with South African strains, where subtype D occurs only in isolated cases. Our results suggest the successful introduction and circulation in Brazil of closely related HIV-1 subtype D strains, possibly of South African origin.