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Relaxation times of choline, creatine and N ‐acetyl aspartate in human cerebral white matter at 1.5 T

2002; Wiley; Volume: 15; Issue: 3 Linguagem: Inglês

10.1002/nbm.762

1099-1492

D.R. Rutgers, Jeroen van der Grond,

Lanthanide and Transition Metal Complexes

Abstract Several studies have investigated the T 1 and T 2 relaxation time of choline, creatine and N ‐acetyl aspartate in cerebral white matter in normal human subjects. However, these studies demonstrate a large variation in T 1 and T 2 values. In the present study, relaxation times of choline, creatine and N ‐acetyl aspartate were determined in cerebral white matter in 15 control subjects (age 21 ± 2 y, mean ± SD) at 1.5 T. Using PRESS, seven or eight data points were obtained to fit the T 1 and T 2 relaxation curves to, respectively. The mean voxel size was 14 cm 3 . The T 1 relaxation times of choline, creatine and N ‐acetyl aspartate were 1091 ± 132 (mean ± SD), 1363 ± 137 and 1276 ± 132 ms. The T 2 relaxation times were 352 ± 52, 219 ± 29 and 336 ± 46 ms, respectively. Copyright © 2002 John Wiley & Sons, Ltd.