Inositol uptake by cultured isolated rat Schwann cells
1984; Elsevier BV; Volume: 120; Issue: 2 Linguagem: Inglês
10.1016/0006-291x(84)91280-4
ISSN1090-2104
AutoresStanton Segal, Shing Mei Hwang, Janet Stern, David Pleasure,
Tópico(s)Nuclear Receptors and Signaling
ResumoThe uptake of radiolabeled myo-inositol by Schwann cells isolated from the sciatic nerve of 2–4 day old rats was found to occur by a saturable, sodium-dependent phlorizin-inhibited mechanism with an estimated Km of 30μM. The system was inhibited by galactose and glucose but not by galactitol. At high concentrations of myo-inositol, a diffusion-like process appeared to be functional. The characteristics of the saturable system are very similar to those of myo-inositol uptake by the endoneural fascicle preparation of sciatic nerve.
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