New ruthenium(II) mixed metallocene derived complexes: Synthesis, characterization by X-ray diffraction and evaluation on DNA interaction by atomic force microscopy
2010; Elsevier BV; Volume: 363; Issue: 14 Linguagem: Inglês
10.1016/j.ica.2010.05.034
ISSN1873-3255
AutoresM. Helena García, Andreia Valente, Pedro R. Florindo, Tânia S. Morais, M. Fátima M. Piedade, M. Teresa Duarte, Virtudes Moreno, Francesc Avilés, J. Loreno,
Tópico(s)Ferrocene Chemistry and Applications
ResumoA new family of Ru(II) mixed metallocene complexes of the type [Ru(η5-C5H5)(η6-arene)][PF6] has been synthesized and fully characterized by NMR and UV–Vis spectroscopy. X-ray analysis of single crystal was achieved for all the complexes and revealed the presence of two enantiomers expected for planar chirality originated by the η6 coordination of the arene prochiral ligands. Studies of interaction of the new complexes with pBR322 DNA by atomic force microscopy showed very strong and different types of interaction. Antiproliferative tests were examined on human leukemia cancer cells (HL-60) using the MTT assay, and the IC50 values revealed low antiproliferative activity compared to cisplatin.
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