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Sodium valproate, GABA and epilepsy

1980; Elsevier BV; Volume: 1; Issue: 2 Linguagem: Inglês

10.1016/0165-6147(80)90014-0

1873-3735

Andy Turner,

Neuroscience and Neuropharmacology Research

Sodium valproate, a branched chain fatty acid, is an effective anti-convulsant drug both in clinical and experimental epilepsies. There is substantial evidence that valproate modifies the metabolism and action of the inhibitory neurotransmitter GABA. Whether this relates to the anti-convulsant action of this drug is still unclear. Possible modes of action of valproate are considered in this article.